Protein Alignment Oatp30B and Slco5a1

DIOPT Version :10

• Sequence 1: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: NP_001423667.1
• Gene: Slco5a1 / 312907
• RGDID: 1307132
• Length: 850
• Species: Rattus norvegicus
• Alignment Length: 876
• Identity: 289/876 - (32%)
• Similarity: 454/876 - (51%)
• Gaps: 132/876 - (15%)

  Fly     7 EQYTNPSFEQESDQPPDPLGGVADVGAGNASSSSNGHIANDAGTANRKGHRRQESMYQMTGLYSE 71
            |.:.:.||..:|...........::.||||    :|.:|  .|:....||:             |
  Rat    25 ENFESESFRSKSLPVLHSASCRQNLSAGNA----DGKLA--LGSIEASGHQ-------------E 70

  Fly    72 TNSGDDSSIDAALDHDSQPHATSYLAGDQLPSTVGSGPGGGGPSAVADSVT--VKCHSRQASAGK 134
            |:.|.:..:                            |....||..|.:.|  :.|:.|:
  Rat    71 THPGRNLIV----------------------------PSPSAPSTSAGTTTELMDCNHRR----- 102

  Fly   135 CPADPEEDFDEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIE 199
               ||.:....    |.....|..|..........:.|:|.:..|..:|..:.|||::|||||||
  Rat   103 ---DPSKTVSV----SSTLATLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIE 160

  Fly   200 KRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPN 264
            :|:.:.||.|||:.|.::|||::.|:||||.|.|...|:|:.:|.:::.||:.:|.:|||...|.
  Rat   161 RRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAIGAALFALPHFISPPY 225

  Fly   265 PGIAIVN--KTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFV 327
            . |..:|  .::|.:|:               :|.|...|.|....:|:   |..|....|.|||
  Rat   226 Q-IQELNASASNDGLCQ---------------NGNSTAILEPPPCPKDS---GGNSHWIYVALFV 271

  Fly   328 LAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSS 392
            .||:|:|.|.:|::|||.||:||:|:.:::|:|:..||.|||.||.||:|||..|:.|::|  ..
  Rat   272 CAQVLIGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMYVMGALGPAVGYLLGGLLIGFYVD--PR 334

  Fly   393 TTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRAT 457
            ..:.:...|.|::|.||.|||||.:.:.:|..|.|:|||.|....||.:|.|           |.
  Rat   335 NPVLLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKFS-----------AD 388

  Fly   458 VATDEMGKVKKLEIVAVTSKEDQSQAPPKVDT-GYGKDIKDIPQSMLRLVKNPVYIVTCLGACME 521
            |.:|:       :|:...|...: |...||.: |:||:::|:|::.:|::.|..::...|....|
  Rat   389 VVSDD-------DIIKEKSNTSE-QVNKKVSSMGFGKNVRDLPRAAVRILSNMTFLFVSLSYTAE 445

  Fly   522 LMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLI 586
            ..||:.|:.|:||::|:||.:..|.|:|:||.|.||.|.:||.|||.|:|:.:|..:.:.:..:|
  Rat   446 SAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMI 510

  Fly   587 TNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPV 651
            .:.:.|.|::.||.:||:::.:.|..|||.|    |.:|..|.: |||.:||..|.|...|.|||
  Rat   511 CSGVSLLCFSTLFIVGCESINLGGINIPYTT----GPSLTMPHR-NLTGSCNVNCGCKIHEYEPV 570

  Fly   652 CGNNGLTYFSPCHAGC--TAFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQ------ALSANE 708
            ||::|:|||:||.|||  :...:|...|||.|.||::.  ..|.....|.::|      ....||
  Rat   571 CGSDGITYFNPCLAGCINSGNLTTGVRNYTECTCVQSR--QVITPPTVGQRSQLRVVIVKTYLNE 633

  Fly   709 NFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQF 773
            |       ..|.:|.|...|.|:.|||:.||.:||:.|..|...:::.||||.:|||.|||||||
  Rat   634 N-------GYAVSGKCKRACNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQF 691

  Fly   774 VIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFM 838
            |:.|...|||.||.||.:||:||:||:..||.:|. |..|::..||:.|.||.|.:|.:..:...
  Rat   692 VLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGS-CWEYNVTSFRFVYFGLAAGLKFVGFIFIF 755

  Fly   839 VDWWLVR-RRKQLEKMK----PLNASDPIIG 864
            :.|:.:: :..:|::.:    ||:.....:|
  Rat   756 LAWYSIKYKEDELQRRRCRDFPLSTVSEHVG 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	215/598 (36%)
		UhpC	<730..795	CDD:441872	35/64 (55%)
Slco5a1	NP_001423667.1	MFS_SLCO5_OATP5	131..676	CDD:340962	215/598 (36%)