DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco5a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	XP_008761717.1	Gene:	Slco5a1 / 312907	RGDID:	1307132	Length:	850	Species:	Rattus norvegicus

Alignment Length:	876	Identity:	289/876 - (32%)
Similarity:	454/876 - (51%)	Gaps:	132/876 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 EQYTNPSFEQESDQPPDPLGGVADVGAGNASSSSNGHIANDAGTANRKGHRRQESMYQMTGLYSE 71
            |.:.:.||..:|...........::.||||    :|.:|  .|:....||:             |
  Rat    25 ENFESESFRSKSLPVLHSASCRQNLSAGNA----DGKLA--LGSIEASGHQ-------------E 70

  Fly    72 TNSGDDSSIDAALDHDSQPHATSYLAGDQLPSTVGSGPGGGGPSAVADSVT--VKCHSRQASAGK 134
            |:.|.:..:                            |....||..|.:.|  :.|:.|:
  Rat    71 THPGRNLIV----------------------------PSPSAPSTSAGTTTELMDCNHRR----- 102

  Fly   135 CPADPEEDFDEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIE 199
               ||.:....    |.....|..|..........:.|:|.:..|..:|..:.|||::|||||||
  Rat   103 ---DPSKTVSV----SSTLATLQERRCLYVVLTDSRCFLVCMCFLTFIQALMVSGYLSSVITTIE 160

  Fly   200 KRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPN 264
            :|:.:.||.|||:.|.::|||::.|:||||.|.|...|:|:.:|.:::.||:.:|.:|||...|.
  Rat   161 RRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAIGAALFALPHFISPPY 225

  Fly   265 PGIAIVN--KTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFV 327
            . |..:|  .::|.:|:               :|.|...|.|....:|:   |..|....|.|||
  Rat   226 Q-IQELNASASNDGLCQ---------------NGNSTAILEPPPCPKDS---GGNSHWIYVALFV 271

  Fly   328 LAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSS 392
            .||:|:|.|.:|::|||.||:||:|:.:::|:|:..||.|||.||.||:|||..|:.|::|  ..
  Rat   272 CAQVLIGMGSTPIYTLGPTYLDDNVKKDNASLYLAIMYVMGALGPAVGYLLGGLLIGFYVD--PR 334

  Fly   393 TTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRAT 457
            ..:.:...|.|::|.||.|||||.:.:.:|..|.|:|||.|....||.:|.|           |.
  Rat   335 NPVLLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFTFPKKLPPRHKKKKKFS-----------AD 388

  Fly   458 VATDEMGKVKKLEIVAVTSKEDQSQAPPKVDT-GYGKDIKDIPQSMLRLVKNPVYIVTCLGACME 521
            |.:|:       :|:...|...: |...||.: |:||:::|:|::.:|::.|..::...|....|
  Rat   389 VVSDD-------DIIKEKSNTSE-QVNKKVSSMGFGKNVRDLPRAAVRILSNMTFLFVSLSYTAE 445

  Fly   522 LMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLI 586
            ..||:.|:.|:||::|:||.:..|.|:|:||.|.||.|.:||.|||.|:|:.:|..:.:.:..:|
  Rat   446 SAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMI 510

  Fly   587 TNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPV 651
            .:.:.|.|::.||.:||:::.:.|..|||.|    |.:|..|.: |||.:||..|.|...|.|||
  Rat   511 CSGVSLLCFSTLFIVGCESINLGGINIPYTT----GPSLTMPHR-NLTGSCNVNCGCKIHEYEPV 570

  Fly   652 CGNNGLTYFSPCHAGC--TAFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQ------ALSANE 708
            ||::|:|||:||.|||  :...:|...|||.|.||::.  ..|.....|.::|      ....||
  Rat   571 CGSDGITYFNPCLAGCINSGNLTTGVRNYTECTCVQSR--QVITPPTVGQRSQLRVVIVKTYLNE 633

  Fly   709 NFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQF 773
            |       ..|.:|.|...|.|:.|||:.||.:||:.|..|...:::.||||.:|||.|||||||
  Rat   634 N-------GYAVSGKCKRACNTLIPFLVFLFIVTFITACAQPSAIIVTLRSVEDEERPFALGMQF 691

  Fly   774 VIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFM 838
            |:.|...|||.||.||.:||:||:||:..||.:|. |..|::..||:.|.||.|.:|.:..:...
  Rat   692 VLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGS-CWEYNVTSFRFVYFGLAAGLKFVGFIFIF 755

  Fly   839 VDWWLVR-RRKQLEKMK----PLNASDPIIG 864
            :.|:.:: :..:|::.:    ||:.....:|
  Rat   756 LAWYSIKYKEDELQRRRCRDFPLSTVSEHVG 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	249/657 (38%)
		MFS	174..>433	CDD:119392	102/260 (39%)
		MFS	512..>600	CDD:304372	32/87 (37%)
		KAZAL_SLC21	633..684	CDD:238650	26/52 (50%)
Slco5a1	XP_008761717.1	MFS_SLCO5_OATP5	131..676	CDD:340962	215/598 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339149
Domainoid	1	1.000	458	1.000	Domainoid score	I468
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57135
Inparanoid	1	1.050	479	1.000	Inparanoid score	I1417
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	1	1.000	-	-		FOG0007263
OrthoInspector	1	1.000	-	-		oto97977
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	1	1.100	-	-	LDO	PTHR11388
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.800