DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco1a6

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001368859.1	Gene:	Slco1a6 / 28254	MGIID:	1351906	Length:	670	Species:	Mus musculus

Alignment Length:	721	Identity:	218/721 - (30%)
Similarity:	353/721 - (48%)	Gaps:	133/721 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 GIQR---FARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVIT 223
            ||.|   ||:||:|::.| :...:.:.||..|:::::|.:|::|.|.:|..|||..|:|:||::.
Mouse     9 GIHRVRCFAKIKVFLLAL-IWAYISKILSGVYMSTMLTQLERQFNISTSIVGLINGSFEMGNLLV 72

  Fly   224 VIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDM 288
            ::||||.|::.|.|:.||:|..:||:|..:..:|||.
Mouse    73 IVFVSYFGTKLHRPIMIGVGCAVMGLGCFIISLPHFL---------------------------- 109

  Fly   289 DLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGP--------------VLLFVL-AQLLLGCGGS 338
             :||.....:..|.:..:.....|:|.::.|..|              :.::|| ..::.|.|.:
Mouse   110 -MGRYEYETTISPTSNLSSNSFLCVENRSQTLKPTQDPAECVKEIKSLMWIYVLVGNIIRGIGET 173

  Fly   339 PLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGD 401
            |:..||.:|::|..::|:|.:|||.:......||::|:|:|.:..:.::|  |:::..::|||.|
Mouse   174 PIMPLGISYIEDFAKSENSPLYIGILEVGKMIGPILGYLMGPFCANIYVDTGSVNTDDLTITPTD 238

  Fly   402 RRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATV-ATDEMGK 465
            .||||.||.|||:|..:.::.::|||.|||.|.:|.            |.:|...|. |.:|..:
Mouse   239 TRWVGAWWIGFLVCAGVNVLTSIPFFFFPKTLPKEG------------LQDNGDGTENAKEEKHR 291

  Fly   466 VKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVV 530
            .|..|       |:|.            .||:....|..|..||:|::..|.:.:::..|:..|:
Mouse   292 DKAKE-------ENQG------------IIKEFFLMMKNLFCNPIYMLCVLTSVLQVNGVANIVI 337

  Fly   531 FLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICL--- 592
            :.|||||..|.:..::|....|....|....|..:.|.|:|:.::..|.|....|     ||
Mouse   338 YKPKYLEHHFGISTAKAVFLIGLYTTPSVSAGYLISGFIMKKLKITLKKAAIIAL-----CLFMS 397

  Fly   593 ACYAML--FFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQV--NLTAACNFGCECLTSEVEPVCG 653
            .|...|  |.|.||...:||.|..|       ..::|.|.:  ...:.||..|.|||...:||||
Mouse   398 ECLLSLCNFMLTCDTTPIAGLTTSY-------EGIQQSFDMENKFLSDCNTRCNCLTKTWDPVCG 455

  Fly   654 NNGLTYFSPCHAGCTAFSST-SNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVP 717
            ||||.|.|||.|||.....| :|..:.||:|:|::.:||                      .|:.
Mouse   456 NNGLAYMSPCLAGCEKSVGTGANMVFQNCSCIRSSGNSS----------------------AVLG 498

  Fly   718 VATAGP-CATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGY 781
            :...|| ||   ..:..|||:..|..|..:...:|..|:.||.:..||:|..:|:|....|||..
Mouse   499 LCKKGPDCA---NKLQYFLIITVFCCFFYSLATIPGYMVFLRCMKSEEKSLGIGLQAFFMRLFAG 560

  Fly   782 IPAPILFGNLIDSTCILWKS-SCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVR 845
            |||||.||.|||.||:.|.: .|||.|. |..|::..||..|:||.|:::   ..|.:..::::|
Mouse   561 IPAPIYFGALIDRTCLHWGTLKCGEPGA-CRTYEVSSFRRLYLGLPAALR---GSIILPSFFILR 621

  Fly   846 RRKQLE 851
            ..::|:
Mouse   622 LIRKLQ 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	202/674 (30%)
		MFS	174..>433	CDD:119392	80/275 (29%)
		MFS	512..>600	CDD:304372	23/92 (25%)
		KAZAL_SLC21	633..684	CDD:238650	25/51 (49%)
Slco1a6	NP_001368859.1	oat	1..625	CDD:273279	217/717 (30%)
Slco1a6	NP_001368859.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..670
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810