Protein Alignment Oatp30B and Slco1a4

DIOPT Version :10

• Sequence 1: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: NP_109612.1
• Gene: Slco1a4 / 28250
• MGIID: 1351896
• Length: 670
• Species: Mus musculus
• Alignment Length: 714
• Identity: 225/714 - (31%)
• Similarity: 359/714 - (50%)
• Gaps: 137/714 - (19%)

  Fly   161 YGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVI 225
            :|::.|::||.|::.|: ...:.::||..|:||::|.||::|.||:|..|||..|:||||::.:|
Mouse    11 HGVRCFSKIKAFLLALT-CAYVSKSLSGTYMNSMLTQIERQFGIPTSVVGLINGSFEIGNLLLII 74

  Fly   226 FVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDL 290
            ||||.|::.|.|:.||:|..:||:|..:..:|||.                             :
Mouse    75 FVSYFGTKLHRPIMIGVGCAVMGLGCFLISIPHFL-----------------------------M 110

  Fly   291 GRLSSGLSNQPLAPHTLREDNCLEGKASTTGP--------------VLLFVL-AQLLLGCGGSPL 340
            ||.....:..|.:..:.....|.|.:..|..|              :.::|| ..::.|.|.:|:
Mouse   111 GRYEYETTILPTSNLSSNSFVCTENRTQTLKPTQDPTECVKEMKSLMWIYVLVGNIIRGMGETPI 175

  Fly   341 FTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRR 403
            ..||.:|::|..::|:|.:|||.:.:....||::|.|||:...:.::|  |:::..::|||.|.|
Mouse   176 MPLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLGSSCANIYVDTGSVNTDDLTITPTDTR 240

  Fly   404 WVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATV-ATDEMGKVK 467
            |||.||.|||:|..:.::.::|||.|||.|.:|.            |.:|...|. |.:|..:.|
Mouse   241 WVGAWWIGFLVCAGVNILTSIPFFFFPKTLLKEG------------LQDNGDGTENAKEEKHREK 293

  Fly   468 -KLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFV-- 529
             |.|...:|                    ||....|..|..||:|::..|   :.::.|:.|:
Mouse   294 IKEENRGIT--------------------KDFFLFMKSLSCNPIYMIFIL---ISVIQVNAFINS 335

  Fly   530 -VFLPKYLETQFSLGKSQANI--FTGSIAVPGACIGIFLGGCILKRFQLKPKGA--VQFVLITNV 589
             .|:|||||.|:  |||.|.|  ..|...:|..|:|..:||.|:|:|::..|.|  :.|.|....
Mouse   336 FTFMPKYLEQQY--GKSTAEIVFLMGLYMLPPICLGYLIGGLIMKKFKITVKKAAYIGFWLSLTE 398

  Fly   590 ICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQV--NLTAACNFGCECLTSEVEPVC 652
            ..|:..:  :.:.|||..:||.|..|       ..::.|..|  |:.|.||..|.|||:..:|||
Mouse   399 YLLSFVS--YIMTCDNFPVAGLTTSY-------EGVQHPLYVENNVLADCNTKCSCLTNTWDPVC 454

  Fly   653 GNNGLTYFSPCHAGCTAFSST-SNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVV 716
            |:|||:|.|.|.|||.....| :|..:.||:|::::.::|                      .|:
Mouse   455 GDNGLSYMSACLAGCEKSVGTGTNMVFQNCSCIQSSGNAS----------------------AVL 497

  Fly   717 PVATAGP-CATPCRTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFG 780
            .:...|| ||   ..:..|||:.....|:.:...:|..|::||.:..||:|..:|:.....|:.|
Mouse   498 GLCDKGPECA---NKLQYFLIISIIGCFIFSLGAIPGYMVLLRCMKSEEKSLGVGLHTFCMRILG 559

  Fly   781 YIPAPILFGNLIDSTCILWKS-SCGEKGGRCLIYDIEKFRYKYVGLCASVK----LIALVIFMV 839
            .|||||.||.|||.||:.|.: .|||.|. |.:|||..||..|:||.|:::    |.||.|.::
Mouse   560 GIPAPIYFGALIDRTCLHWGTLKCGEPGA-CRMYDINSFRRIYLGLPAALRGASFLPALFILIL 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	183/617 (30%)
		UhpC	<730..795	CDD:441872	24/64 (38%)
Slco1a4	NP_109612.1	oat	1..625	CDD:273279	225/714 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..670