DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco1a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_038825.1	Gene:	Slco1a1 / 28248	MGIID:	1351891	Length:	670	Species:	Mus musculus

Alignment Length:	700	Identity:	211/700 - (30%)
Similarity:	341/700 - (48%)	Gaps:	141/700 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 FARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYL 230
            |:::|:|::.|: ...:.::||..|:||::|.||::|.||:|..|.|..|:||||::.::||||.
Mouse    16 FSKMKVFLMSLT-CAYLAKSLSGVYMNSMLTQIERQFGIPTSVVGFITGSFEIGNLLLIVFVSYF 79

  Fly   231 GSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSS 295
            |.:.|.|:.||:|.|:||:|..:...|||.                             :||...
Mouse    80 GRKLHRPIIIGVGCVVMGLGCFLMASPHFL-----------------------------MGRYKY 115

  Fly   296 GLSNQPLAPHTLREDNCLEGKASTTGPV---------------LLFVLAQLLLGCGGSPLFTLGT 345
            ..:..|.:..:.....|:|.:..|..|.               :..::...:.|.|.:|:..||.
Mouse   116 ETTISPTSNLSSNSFLCIENRTQTLKPTQDPTECVKEIKSLMWIYVLIGNTMRGIGETPIMPLGI 180

  Fly   346 TYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMW 408
            :|::|..::|:|.:|||.:......||::|.|||::....::|  |:::..::|||.|.||||.|
Mouse   181 SYIEDFAKSENSPLYIGILEMGKIVGPIIGLLLGSFFARVYVDIGSVNTDDLTITPTDTRWVGAW 245

  Fly   409 WGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVA 473
            |.|||:|..:.::.::|||.|||.|.:::            |.:|...|       |.:|:
Mouse   246 WIGFLVCAGVNILTSIPFFFFPKTLPKKE------------LQDNVDVT-------KYEKV---- 287

  Fly   474 VTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFV---VFLPKY 535
                |...:...|.:.|..||.....:|   |..||:|::..|.:.::   ::||.   .|||||
Mouse   288 ----EKHRERAKKENLGITKDFLPFMKS---LCCNPIYMLFSLTSVLQ---INGFASTFTFLPKY 342

  Fly   536 LETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAV----------QFVLITNVI 590
            ||.|:....|:|....|..::|..|:|..:.|.|:|:|::..|.|.          .|:.:.|
Mouse   343 LEQQYGKSTSEAVFLIGVYSLPPVCLGYLISGFIMKKFKITVKKAAYIAFGLSLSEYFIFLCN-- 405

  Fly   591 CLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPF--QVNLTAACNFGCECLTSEVEPVCG 653
                    :.|.|||..:||.|..|       ..::.|.  :.|:.|.||..|.|||...:||||
Mouse   406 --------YLLTCDNFPVAGLTTSY-------KGVQHPLYGEKNVLADCNTRCSCLTDTWDPVCG 455

  Fly   654 NNGLTYFSPCHAGCTAFSST-SNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVP 717
            :|||.|.|.|.|||.....| :|..:.||:|:          |:.|:.:            .|:.
Mouse   456 DNGLAYMSACLAGCEKSVGTGTNMVFQNCSCI----------GSSGNSS------------AVLG 498

  Fly   718 VATAGPCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGY 781
            :...||   .| ..:..|||...|.:|:.:...:|..|::||.|..||:|..:|:.....||...
Mouse   499 LCKKGP---ECDNKLQYFLIKSVFSSFIFSLAAIPGYMVLLRCVKSEEKSIGVGLHAFFIRLLAG 560

  Fly   782 IPAPILFGNLIDSTCILWKS-SCGEKGGRCLIYDIEKFRYKYVGLCASVK 830
            ||||:.||.|||.||:.|.: .||:.|. |.:|||.:||:.|:||.|:|:
Mouse   561 IPAPVYFGALIDRTCLHWGTLKCGQPGA-CRMYDINRFRHIYLGLPAAVR 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	202/681 (30%)
		MFS	174..>433	CDD:119392	84/275 (31%)
		MFS	512..>600	CDD:304372	25/100 (25%)
		KAZAL_SLC21	633..684	CDD:238650	24/51 (47%)
Slco1a1	NP_038825.1	oat	1..625	CDD:273279	211/699 (30%)
		MFS	23..>396	CDD:119392	123/435 (28%)
		KAZAL_SLC21	436..488	CDD:238650	25/61 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810