Protein Alignment Oatp30B and SLCO1B3

DIOPT Version :10

• Sequence 1: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: NP_062818.1
• Gene: SLCO1B3 / 28234
• HGNCID: 10961
• Length: 702
• Species: Homo sapiens
• Alignment Length: 770
• Identity: 241/770 - (31%)
• Similarity: 382/770 - (49%)
• Gaps: 129/770 - (16%)

  Fly   170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRR 234
            |:|:..|| ...:.:||....:...||.||:||:|.||.:|||..|:||||::.::||||.||:.
Human    28 KMFLAALS-FSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKL 91

  Fly   235 HIPVWIGIGAVIMGIGSLVFMVPHF---------TGEPNPGIAIVNKTSDNICKSALVRDQDMDL 290
            |.|..||||.::||.||::..:|||         ....||        |:|...|
Human    92 HRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINP--------SENSTSS---------- 138

  Fly   291 GRLSSGLSNQPL-----APHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDD 350
              ||:.|.||.|     :|..:.:| |:  |.|.:...:...:..:|.|.|.:|:..||.:|:||
Human   139 --LSTCLINQTLSFNGTSPEIVEKD-CV--KESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDD 198

  Fly   351 HVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMWWGGFL 413
            ..:...||:|:|.:.::|..|||:||.||:.....::|  .:..:||.|||.|.||||.||.|||
Human   199 FAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFL 263

  Fly   414 LCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKE 478
            :.|:..::.::|||..||...:.:|: ||.|:...||..|                        :
Human   264 VSGLFSIISSIPFFFLPKNPNKPQKE-RKISLSLHVLKTN------------------------D 303

  Fly   479 DQSQAPPKVDTGYG--KDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFV---VFLPKYLET 538
            |::|.....:.|..  |::....||:..::.||:|::..|   :.|:.||.|:   .::.||:|.
Human   304 DRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLL---LTLLQVSSFIGSFTYVFKYMEQ 365

  Fly   539 QFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGC 603
            |:....|.||...|.|.:|....|:||||.|:|:|:|...|..:|..:|::|......:.|.|.|
Human   366 QYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLIC 430

  Fly   604 DNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCT 668
            ::..:||.|:.|..:|...|.::.|.     :.||..|.|..|:.||||||||:||.|||.|||.
Human   431 ESKSVAGLTLTYDGNNSVASHVDVPL-----SYCNSECNCDESQWEPVCGNNGITYLSPCLAGCK 490

  Fly   669 AFSS-TSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCA---TPCR 729
            :.|. ..:|.:.||:||...          |.|      |.|::       |..|.|.   |..|
Human   491 SSSGIKKHTVFYNCSCVEVT----------GLQ------NRNYS-------AHLGECPRDNTCTR 532

  Fly   730 TIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDS 794
            ..:.::.:....:...|:.....:::.::.|..|.::.|:|.|.::.|..|.|.|||.||.|||.
Human   533 KFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDK 597

  Fly   795 TCILWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQLEKMKPLNA 858
            ||:.|. :|||.:|. |.||:...|...|:||..:::..|||:::|..:.::::.|   .|...|
Human   598 TCMKWSTNSCGAQGA-CRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQ---GKDTKA 658

  Fly   859 SDPIIGSIISLDKLFEEKLSGAEPSTAFVGGGGELIIPTDILRHSRNDSRTMHMD 913
            ||             .|:....|.:..|: ..||..:|:     :..||:|.::|
Human   659 SD-------------NERKVMDEANLEFL-NNGEHFVPS-----AGTDSKTCNLD 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	192/612 (31%)
		UhpC	<730..795	CDD:441872	17/64 (27%)
SLCO1B3	NP_062818.1	MFS	28..561	CDD:475125	192/612 (31%)