DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and SLCO3A1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_037404.2	Gene:	SLCO3A1 / 28232	HGNCID:	10952	Length:	710	Species:	Homo sapiens

Alignment Length:	805	Identity:	266/805 - (33%)
Similarity:	404/805 - (50%)	Gaps:	147/805 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GSGPG---GGGPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGDCGILNCRPYGIQRFA 167
            |..||   |||.|                 |:...| |...::::.:...|            |:
Human     3 GKKPGGSSGGGRS-----------------GELQGD-EAQRNKKKKKKVSC------------FS 37

  Fly   168 RIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGS 232
            .||||:| ....:|:.|.....|:.||:||:|:||.:.|:..|:||||:||||:..::||||.|:
Human    38 NIKIFLV-SECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGA 101

  Fly   233 RRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSGL 297
            |.|.|..||.|.::|.:|:|:..:|.|                      |......:.|.:..|.
Human   102 RGHRPRLIGCGGIVMALGALLSALPEF----------------------LTHQYKYEAGEIRWGA 144

  Fly   298 SNQPLAPHTLREDNC-LEGKASTTGP---------------VLLFVLAQLLLGCGGSPLFTLGTT 346
            ..:         |.| ..|.....||               .||.:.||:|||.|.:|:..||.:
Human   145 EGR---------DVCAANGSGGDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVS 200

  Fly   347 YVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS--LSSTTISITPGDRRWVGMWW 409
            |:|||||.:.||:|||.:::|..|||..||:||::....::|:  :.::.:.|||.|.||:|.||
Human   201 YIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWW 265

  Fly   410 GGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAV 474
            |||||||.:|...::..|.||:.|....:...:|          .:|.::..|..:.|....|..
Human   266 GGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMES----------EQAMLSEREYERPKPSNGVLR 320

  Fly   475 TSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQ 539
            ...|..|.|      ...:.::.||:....|:.|||:....|.||||:.:|:||..||.||||.|
Human   321 HPLEPDSSA------SCFQQLRVIPKVTKHLLSNPVFTCIILAACMEIAVVAGFAAFLGKYLEQQ 379

  Fly   540 FSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCD 604
            |:|..|.||...|..|:|.||:||||||.::|:..|...||::..::.|::..|||....|||||
Human   380 FNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCD 444

  Fly   605 NLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTA 669
            ...:||.|:||..|...||.|: |:     :.||..|||.|....||||.:|:||.|.|.|||
Human   445 TGPVAGVTVPYGNSTAPGSALD-PY-----SPCNNNCECQTDSFTPVCGADGITYLSACFAGC-- 501

  Fly   670 FSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATP-CRTIY- 732
                ::||.|.|||:                  .....||   .||||    |.|.:| |:..:
Human   502 ----NSTNLTGCACL------------------TTVPAEN---ATVVP----GKCPSPGCQEAFL 537

  Fly   733 PFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCI 797
            .||.::...:.:.|..|.|.::|::|:||.|.:|:|||:.|::.||.|:||.|::||..|||||:
Human   538 TFLCVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCL 602

  Fly   798 LWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRR--RKQLEKMKPLNASD 860
            .|.:.|||:|. |::||...:||.||.:..::|..|.:::...|..:|:  ::.::..:...::.
Human   603 FWSTFCGEQGA-CVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTS 666

  Fly   861 PIIGSIISLDKLFEEKLSGAEPSTA 885
            ....|.::||.|      |.:|..|
Human   667 EFFASTLTLDNL------GRDPVPA 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	237/666 (36%)
		MFS	174..>433	CDD:119392	96/276 (35%)
		MFS	512..>600	CDD:304372	39/87 (45%)
		KAZAL_SLC21	633..684	CDD:238650	23/50 (46%)
SLCO3A1	NP_037404.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		10/39 (26%)
		OATP	41..619	CDD:281175	236/663 (36%)
		MFS	47..>286	CDD:119392	93/269 (35%)
		KAZAL_SLC21	467..511	CDD:238650	23/54 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5914
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3818
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.750