DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco2a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_073158.2	Gene:	Slco2a1 / 24546	RGDID:	3051	Length:	644	Species:	Rattus norvegicus

Alignment Length:	760	Identity:	241/760 - (31%)
Similarity:	374/760 - (49%)	Gaps:	153/760 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 PG---GGGPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGDCGILNCRPYGIQRFARIK 170
            ||   |.|.|:|.|.             :||...                          |:.||
  Rat     7 PGARQGSGTSSVPDR-------------RCPRSV--------------------------FSNIK 32

  Fly   171 IFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRH 235
            :||:...|| .:.|.|.|.|..|.:|||||||.:.||.||||:|..||.|...:||:||.|||.:
  Rat    33 VFVLCHGLL-QLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNATLIIFISYFGSRVN 96

  Fly   236 IPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIV--NKTS--DNICKSALVRDQDMDLGRLSSG 296
            .|..||||.:::..|:.|..:|||..||....:..  |::|  .::|:..|   ..:...:..|
  Rat    97 RPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYTSTTDGNRSSFQTDLCQKHL---PALPPSKCHS- 157

  Fly   297 LSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYI 361
                 ..|.|.:|.:.|.|         |.|:||||.|.|..|:...|.:||||.....:|.:||
  Rat   158 -----TVPDTHKETSSLWG---------LMVVAQLLAGIGTVPIQPFGISYVDDFAEPTNSPLYI 208

  Fly   362 GFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAV 424
            ..::::..|||..|:|||:.:|...:|  .:.:.|::::|||.||:|.||.|.|:....|:|.::
  Rat   209 SILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSL 273

  Fly   425 PFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDT 489
            |||.||:.::|                 .:..:|..:|..|          ::||:|:
  Rat   274 PFFFFPRAMSR-----------------GAERSVTAEETMK----------TEEDKSR------- 304

  Fly   490 GYGKD-IKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGS 553
            |...| ||..|:..|||:.||::::..|..|....:::|...||.|:||.|:....:.||...|:
  Rat   305 GSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYGATAAYANFLIGA 369

  Fly   554 IAVPGACIGIFLGGCILKRF----QLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIP 614
            :.:|.|.:|:..||.::|||    |..|:.|...:.|:.::|:.    |||:||....:|....|
  Rat   370 VNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIITISMILCVP----LFFMGCSTSAVAEVYPP 430

  Fly   615 YYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTAFSSTSNTN-- 677
            ..:|:.|.   :||      .||...|.|..|...||||:||:.|.|||||||::.:::|..:
  Rat   431 STSSSIHP---QQP------PACRRDCSCPDSFFHPVCGDNGVEYVSPCHAGCSSTNTSSEASKE 486

  Fly   678 --YTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATPC-RTIYPFLILLF 739
              |.||:||           :|||.:                 |..|.|.|.| :.:.|.:.|:.
  Rat   487 PIYLNCSCV-----------SGGSAS-----------------AKTGSCPTSCAQLLLPSIFLIS 523

  Fly   740 FMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKSSCG 804
            |...:...:..||.|:|||.|:::|:|||:|:||::.||..::|||.|:|.||||:|:.|...|.
  Rat   524 FAALIACISHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPAPSLYGLLIDSSCVRWNYLCS 588

  Fly   805 EKGGRCLIYDIEKFRYKYVGLCASVKLI-ALVIFMVDWWLVRRRK 848
            .:.|.|..||.:..|.:|:||....|.: .|::|.:.|.:.:.|:
  Rat   589 GRRGACAYYDNDALRNRYLGLQMVYKALGTLLLFFISWRMKKNRE 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	220/662 (33%)
		MFS	174..>433	CDD:119392	97/264 (37%)
		MFS	512..>600	CDD:304372	26/91 (29%)
		KAZAL_SLC21	633..684	CDD:238650	23/54 (43%)
Slco2a1	NP_073158.2	oat	1..630	CDD:273279	240/755 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		6/12 (50%)
		MFS	<166..>425	CDD:119392	93/305 (30%)
		KAZAL_SLC21	442..496	CDD:238650	25/64 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810