DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco5a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_766429.2	Gene:	Slco5a1 / 240726	MGIID:	2443431	Length:	850	Species:	Mus musculus

Alignment Length:	824	Identity:	280/824 - (33%)
Similarity:	438/824 - (53%)	Gaps:	128/824 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 KIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRR 234
            :.|:|.:..|..:|..:.|||::|||||||:|:.:.||.|||:.|.::|||::.|:||||.|.|.
Mouse   131 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRG 195

  Fly   235 HIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVN--KTSDNICKSALVRDQDMDLGRLSSGL 297
            ..|:|:.:|.:::.||:.:|.:|||...|.. |..:|  .::|.:|:               :|.
Mouse   196 RRPLWLAVGGLLIAIGAALFALPHFISPPYQ-IQELNASASNDGLCQ---------------NGN 244

  Fly   298 SNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIG 362
            |...|.|....:|:   |..|....|.|||.||:|:|.|.:|::|||.||:||:|:.:::|:|:.
Mouse   245 STAILEPPPCPKDS---GGNSHWIYVALFVCAQVLIGMGSTPIYTLGPTYLDDNVKKDNASLYLA 306

  Fly   363 FMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFF 427
            .||.|||.||.||:|||..|:.|::|  ....:.:...|.|::|.||.|||||.:.:.:|..|.|
Mouse   307 IMYVMGALGPAVGYLLGGLLIGFYVD--PRNPVHLDQSDPRFIGNWWSGFLLCAIAMFLVIFPMF 369

  Fly   428 SFPKVL-AREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGY 491
            :|||.| .|.|||.:.|:.|           |..|::.|.|     :.||::...:..|   .|:
Mouse   370 TFPKKLPPRHKKKKKFSADV-----------VIDDDIIKEK-----SNTSEQMNKKVSP---MGF 415

  Fly   492 GKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAV 556
            ||:::|:|::.:|::.|..::...|....|..||:.|:.|:||::|:||.:..|.|:|:||.|.|
Mouse   416 GKNVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIV 480

  Fly   557 PGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKH 621
            |.|.:||.|||.|:|:.:|..:.:.:..:|.:.:.|.|::.||.:||:::.:.|..|||.|
Mouse   481 PSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCESINLGGINIPYTT---- 541

  Fly   622 GSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGC--TAFSSTSNTNYTNCACV 684
            |.:|..|.: |||.:||..|.|...|.|||||::|:|||:||.|||  :...:|...|||.|.||
Mouse   542 GPSLTMPHR-NLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCINSGNLTTGVRNYTECTCV 605

  Fly   685 RANISSSIYRGAGGSQAQ------ALSANENFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTF 743
            ::.  ..|.....|.::|      ....|||       ..|.:|.|...|.|:.|||:.||.:||
Mouse   606 QSR--QVITPPTVGQRSQLRVVIVKTYLNEN-------GYAVSGKCKRTCNTLIPFLVFLFIVTF 661

  Fly   744 LVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGG 808
            :.|..|...:::.||||.:|||.||||||||:.|...|||.||.||.:||:||:||:..||.:|.
Mouse   662 ITACAQPSAIIVTLRSVEDEERPFALGMQFVLLRTLAYIPTPIYFGAVIDTTCMLWQQECGVQGS 726

  Fly   809 RCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRRRKQ-LEKMK----PLNASDPIIGSIIS 868
             |..|::..||:.|.||.|.:|.:..:...:.|:.::.::. |::.:    ||:.....:|
Mouse   727 -CWEYNVTSFRFVYFGLAAGLKFVGFIFIFLAWYSIKYKEDGLQRRRCREFPLSTVSEQVG---- 786

  Fly   869 LDKLFEEKLSGAEPSTAFVGGGGELIIPTDILRHSRNDSRTMHMDYCYDKCGRVVTPANTCNQPQ 933
                        :||.|              .::||..|                     |....
Mouse   787 ------------QPSKA--------------EKYSRTTS---------------------CPAFS 804

  Fly   934 TKSKKHFRSA-----SCDVKMIKS-FARDHSSSSGPADAAGQDA 971
            |:.:.|..:|     .|..:.... |:...|||:.|......||
Mouse   805 TQGEVHEETALQKGFPCTTQTYPGPFSEAVSSSADPGQDESPDA 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	250/657 (38%)
		MFS	174..>433	CDD:119392	102/260 (39%)
		MFS	512..>600	CDD:304372	32/87 (37%)
		KAZAL_SLC21	633..684	CDD:238650	26/52 (50%)
Slco5a1	NP_766429.2	MFS_SLCO5_OATP5	131..676	CDD:340962	216/598 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835524
Domainoid	1	1.000	458	1.000	Domainoid score	I492
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H57135
Inparanoid	1	1.050	480	1.000	Inparanoid score	I1450
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	1	1.000	-	-		FOG0007263
OrthoInspector	1	1.000	-	-		oto94464
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	1	1.100	-	-	LDO	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.800