DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco2a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_201571.2	Gene:	Slco2a1 / 24059	MGIID:	1346021	Length:	643	Species:	Mus musculus

Alignment Length:	714	Identity:	243/714 - (34%)
Similarity:	364/714 - (50%)	Gaps:	121/714 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 FARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYL 230
            |..||:||:...|| .:.|.|.|.|..|.:|||||||.:.||.||||:|..||.|.|.:|||||.
Mouse    28 FNNIKVFVLCHGLL-QLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYF 91

  Fly   231 GSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDN-------ICKSALVRDQDM 288
            |||.:.|..||||.:::..|:.|..:|||..||   ....:.|:.|       :|:..|.
Mouse    92 GSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEP---YQYASTTAGNSSHFQTDLCQKHLP----- 148

  Fly   289 DLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDDHVR 353
              |.|.|...:  ..|.|.:|         |:....|.|:||||.|.|..|:...|.:||||...
Mouse   149 --GLLPSKCHS--TVPDTQKE---------TSSMWSLMVVAQLLAGVGTVPIQPFGISYVDDFAE 200

  Fly   354 TESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWVGMWWGGFLLCG 416
            ..:|.:||..::::..|||..|:|||:.:|...:|  .:.:.|::::|||.||:|.||.|.|:..
Mouse   201 PTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISS 265

  Fly   417 VILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQS 481
            ..|:|.::|||.||:.::|                ...|:.:|.:.|    |:|       ||:|
Mouse   266 GFLIVTSLPFFFFPRAMSR----------------GAERSVIAEETM----KME-------EDKS 303

  Fly   482 QAPPKVDTGYGKD-IKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKS 545
            :       |...| ||..|:..|||:.||::::..|..|....:::|...||.|:||.|:....:
Mouse   304 R-------GSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYDASAA 361

  Fly   546 QANIFTGSIAVPGACIGIFLGGCILKRF----QLKPKGAVQFVLITNVICLACYAMLFFLGCDNL 606
            .||:..|::.:|.|.:|:..||.::|||    |..|:.|...:.|:.::|    |.|||:||...
Mouse   362 YANLLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIMTISIILC----APLFFMGCSTP 422

  Fly   607 KMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTAFS 671
            .:|....|...|:.|    .||      .||...|.|..|...||||:||:.|.|||||||::.:
Mouse   423 AVAEVYPPSTPSSIH----PQP------PACRRDCLCPDSVFHPVCGDNGVEYLSPCHAGCSSLN 477

  Fly   672 STSNTN----YTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATPC-RTI 731
            .:|..:    |.||:||           .|||.:                 |..|.|.|.| :.:
Mouse   478 VSSAASKQPIYLNCSCV-----------TGGSAS-----------------AKTGSCPTSCAQLL 514

  Fly   732 YPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTC 796
            .|.:.|:.|:..:...:..||.|:|||.|:::|:|||:|:||::.||..::|:|.|:|.||||:|
Mouse   515 LPSIFLISFVALIACVSHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPSPSLYGLLIDSSC 579

  Fly   797 ILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLI-ALVIFMVDWWLVRRRKQLEKMKPLNAS 859
            |.|...|..:.|.|..||.:..|.:|:||....|:: .|::|.:.|   |.:|..|.....|||
Mouse   580 IRWNYLCSGRRGACAYYDNDALRNRYLGLQVIYKVLGTLLLFFISW---RVKKNREYSLQENAS 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	226/665 (34%)
		MFS	174..>433	CDD:119392	100/267 (37%)
		MFS	512..>600	CDD:304372	27/91 (30%)
		KAZAL_SLC21	633..684	CDD:238650	23/54 (43%)
Slco2a1	NP_201571.2	oat	1..629	CDD:273279	238/701 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		MFS	<166..>425	CDD:119392	95/296 (32%)
		KAZAL_SLC21	441..494	CDD:238650	23/52 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810