DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and Y70G10A.3

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_499267.1	Gene:	Y70G10A.3 / 190573	WormBaseID:	WBGene00013499	Length:	690	Species:	Caenorhabditis elegans

Alignment Length:	760	Identity:	208/760 - (27%)
Similarity:	367/760 - (48%)	Gaps:	108/760 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 DPEEDF-----DEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITT 197
            :|:|:.     ||:......||...|.|..:|.|...|..:|:|.:...:|..:.:......::|
Worm    11 EPDENLKHKIEDEDDAEKLLCGYGACTPSWLQGFHNAKCLLVVLGICAFIQSFVVNAIFPVGLST 75

  Fly   198 IEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGE 262
            :|:||::.|:::|:|:|.|:...::.|..|.:.|:..|...|||.|.|||.:|||:..:||:..:
Worm    76 LERRFKMTSTHTGIISSWYDFAVLLVVFPVCHWGNNGHKGRWIGWGGVIMALGSLICALPHWMVD 140

  Fly   263 -PNPGI-AIVNKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVL- 324
             .:|.: .:.|:|....|.:   ||.....|:           ||           :|...|..
Worm   141 IYHPDVNDLTNQTDFGQCAN---RDDPECAGK-----------PH-----------SSWFNPYFW 180

  Fly   325 LFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS 389
            :|:|.|.|.|.|.:|||::||||:|::|..::|.:|:.....:.:||||:|...|.:||:.:.|.
Worm   181 MFILGQTLHGVGSTPLFSIGTTYMDENVSQKASPVYLAIHAVLTSFGPVIGVFAGGFLLNLYDDF 245

  Fly   390 LSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNS 454
            .....|.:...|.||||.||.||::..:..|::|.|..:|    |||             ||...
Worm   246 DRVERIPMERSDPRWVGAWWVGFIISSISALMIAFPILAF----ARE-------------LPEAK 293

  Fly   455 RATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGAC 519
            |        .:.|.:....|.:.:..::||        :|:..:|..:.:::.||.::|......
Worm   294 R--------HRAKDVNQCHVANGDVNAKAP--------RDLMKLPACVWKILSNPTFLVCIFVGI 342

  Fly   520 MELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFV 584
            .|.:|::||..|:||.|||..|...:.|: :..|:.:..|..|:.:||.|:::.:|:..|.::.:
Worm   343 FESIIINGFAAFMPKILETLLSTNPTLAS-YLSSVVIFAAATGVMVGGTIIRQLKLQVGGMLKMI 406

  Fly   585 LITNVICLACYAMLFFLG----CDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLT 645
            ::.:|     :|:||..|    |...:..|..:.|     ...::|:....::::.||..|.| .
Worm   407 IVCHV-----FALLFTTGLLSHCPQREFVGINLGY-----EDLSIEKMHDFSISSTCNADCHC-K 460

  Fly   646 SEVEPVCG-NNGLTYFSPCHAGCTAFSS-TSNTNYTNCACVRANISSSIYRGAGGSQAQALSANE 708
            .|..|||. |.|..|:|.||||||..:: ..::.::.|.|:.:|  |:.:....|.:...
Worm   461 MEWNPVCDRNTGHMYYSACHAGCTGRTTIDGSSQWSGCGCLTSN--STFHNLIHGIKEHP----- 518

  Fly   709 NFAEVTVVPVATAGPCATPCRTIYPFLILLFFMTFLVAS--TQMPLLMIVLRSVSEEERSFALGM 771
                    .|...|.|...|......|::..|:| :|||  :.:|...|:||.|..::|:.|||:
Worm   519 --------DVLNQGYCHQDCGYREYILMVTLFIT-VVASFASGIPTQQIMLRVVPFDQRTLALGV 574

  Fly   772 QFVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVI 836
            .:...||.|:||..||||.:||:.|:.|..||| |...||:||..|..:...||....||::::.
Worm   575 NWTFVRLLGFIPGGILFGIIIDTACLEWGESCG-KATSCLVYDPFKLSWTITGLAIVCKLLSILA 638

  Fly   837 FMVDWWLVRRRKQLEKMKPLNASD----PIIGSIISLDKLFEEKL 877
            .::. ::..|...|:....:...|    ..:..:::.|:|.|:.:
Worm   639 TIIG-YMTYRPSDLDNAGSIQTVDSHCHTALHLVVNDDRLPEQAI 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	186/657 (28%)
		MFS	174..>433	CDD:119392	79/261 (30%)
		MFS	512..>600	CDD:304372	24/87 (28%)
		KAZAL_SLC21	633..684	CDD:238650	19/52 (37%)
Y70G10A.3	NP_499267.1	OATP	49..620	CDD:281175	186/657 (28%)
		MFS	51..>421	CDD:119392	119/433 (27%)
		KAZAL_SLC21	449..500	CDD:238650	19/51 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720