DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and K02G10.5

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001294796.1	Gene:	K02G10.5 / 180742	WormBaseID:	WBGene00019346	Length:	642	Species:	Caenorhabditis elegans

Alignment Length:	762	Identity:	191/762 - (25%)
Similarity:	328/762 - (43%)	Gaps:	148/762 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 DEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSY 208
            ||..|     |....||.|:|..:....|:.:||...|:|.|:.:|.::..|::|||||::.|:.
Worm     5 DETPF-----GFSWFRPKGLQWLSNFIPFMSILSANAMLQGAIVNGLVSVSISSIEKRFKLTSTQ 64

  Fly   209 SGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKT 273
            ||:.|::|::...:.:|.::...::.:....||:|.:|:||||::.::|.:|..|..    |.:.
Worm    65 SGIFAATYDVFVTVMLIPLALYATKVNKVKCIGLGMMIVGIGSILVIIPEYTAGPYS----VGEV 125

  Fly   274 SDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTG---PVLLFVLAQLLLGC 335
            ..::|                  ::..|       :..|.||.:.|..   .:||.:|:|..:|.
Worm   126 KKDVC------------------VTGGP-------DKVCSEGSSDTFSAHRELLLLLLSQAFVGI 165

  Fly   336 GGSPLFTLGTTYVDD---HVRT-ESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD-SLSSTTI 395
            |.|||||.|.|.:|:   |.|| .:.::|:    .....||.:.|:...::|....| ..|...:
Worm   166 GASPLFTYGITCLDEFDSHKRTGRNLALYM----IASTVGPALAFVGCGFMLRLWGDWRTSPAEM 226

  Fly   396 SI-TPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVA 459
            .| ...|.|::||||.||::||.:.|..|.|...|||.|  :...:||::.|.
Worm   227 GIDNSADPRFIGMWWIGFVVCGFVALFTAFPLIMFPKRL--KDTTVRKANDVH------------ 277

  Fly   460 TDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLV----KNPVYIVTCLGACM 520
                                      :.|....||..|......:::    ||...:...|...:
Worm   278 --------------------------RTDASLDKDFSDHKYEFFKIIFMLFKNKTCMCVILMQTI 316

  Fly   521 ELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVL 585
            |.|:::|::.|:||.|||........|::.||.:.||...:..::||.|.|.|:.:.|.::.||:
Worm   317 EAMLMNGYITFIPKLLETLLGFSSGNASLITGGVVVPVGIVASYIGGRISKLFENRFKPSMYFVI 381

  Fly   586 ITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEP 650
            :..::...|.:.| .:.|::|.:.|..:|.....::|: ||         .|:..|.| .|...|
Worm   382 VFGIMAAGCSSCL-LIRCESLNVYGVNVPSSDLPRYGA-LE---------TCSENCHC-DSFFNP 434

  Fly   651 VCGNNG-LTYFSPCHAGCTAFSST--SNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAE 712
            ||..:. ||:.|||||||......  ..:|:|||.|.:..|
Worm   435 VCSEDSKLTFLSPCHAGCADMPGIKFGASNWTNCGCSKNTI------------------------ 475

  Fly   713 VTVVPVATAGPCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIF 776
                  ...|.|...| :.||.|:|:...::|.:..|...|....||.|:.:.|.......::..
Worm   476 ------VKKGYCDASCQKQIYQFIIMFIALSFCIFITAPVLQSSSLRVVNHKHRDHFTCFGWLWM 534

  Fly   777 RLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLI-ALVIFMVD 840
            |:.|.||..|:||.:||..|:.|:..|..:  :|..|:.....:.:.....:||.. .:::|:..
Worm   535 RILGSIPGAIVFGYIIDVNCMYWQKDCVSQ--KCQFYNASNLGWAFFYFTIAVKFTGGILLFLAA 597

  Fly   841 WWLVRRRKQ--LEKMKPLNASDPIIGSIISLDKLFEEKL-SGAEPST 884
            :......|.  .|..:.|...     :..|:...:|:.| ||..|.|
Worm   598 YCYQESDKSNGKESCRTLETD-----TSESVKMSYEKNLPSGLSPET 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	170/663 (26%)
		MFS	174..>433	CDD:119392	77/267 (29%)
		MFS	512..>600	CDD:304372	25/87 (29%)
		KAZAL_SLC21	633..684	CDD:238650	20/53 (38%)
K02G10.5	NP_001294796.1	oat	1..602	CDD:273279	181/718 (25%)
		MFS	36..>390	CDD:119392	108/426 (25%)
		KAZAL_SLC21	421..470	CDD:238650	20/49 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820