DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and F53B1.8

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001294793.1	Gene:	F53B1.8 / 180528	WormBaseID:	WBGene00018739	Length:	801	Species:	Caenorhabditis elegans

Alignment Length:	832	Identity:	236/832 - (28%)
Similarity:	370/832 - (44%)	Gaps:	154/832 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 SETNS--GDDSSIDAALDHDSQPHATSYLAGDQLPSTVGSGPGGGGPSAVADSVTVKCHSRQASA 132
            :||.|  ||..|     ||.|:|....:                             .|.||||.
Worm    17 AETRSCPGDLRS-----DHSSKPTRNKW-----------------------------SHMRQASQ 47

  Fly   133 GKCPADPEEDFDEEQFR------------------SGDCGILNCRPYGIQRFARIKIFVVLLSLL 179
            |..|...|:....::|:                  ...|||...||..:|...:....:|||.:.
Worm    48 GVPPRHMEKALRRKEFQLPPQQHELIEREMTVLTEESQCGIGKWRPKWLQCLGKQLPMIVLLCVY 112

  Fly   180 VMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGA 244
            ..:|..:.:|.:.|.|::||:||:..:|:.|.|...|:.|.|:..|.|||.|.|...|..:..|.
Worm   113 CSIQGLIVNGLVPSAISSIERRFKFSTSHMGRIVQFYDFGYVLLCIPVSYFGGRHSKPAVLAAGL 177

  Fly   245 VIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSG--LSNQPLAPHTL 307
            ..|.:|||:|..||.             .||:...|    ..:|..|..|..  |.|...:|..|
Worm   178 ACMALGSLIFSAPHI-------------MSDSYSAS----QSNMSFGTCSIEHLLQNDMTSPEAL 225

  Fly   308 REDNC----LEGKASTTGPVLLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMG 368
            .:..|    .:..:|:.....||..|..|.|.|.:||||:|.:|:|::|.|..||:::|..||..
Worm   226 AQIQCQSENQDQHSSSNLYFYLFCFAHFLHGIGATPLFTIGVSYIDENVGTAKSSLFVGIFYSFA 290

  Fly   369 AFGPVVGFLLGAYLLSFHMDSL---SSTTISITPG--DRRWVGMWWGGFLLCGVILLVVAVPFFS 428
            .|||.:|||..:..|.:|.|..   ....:.::.|  |..|||.||..|:....:..|..:|..|
Worm   291 VFGPAIGFLGASVSLQYHTDFWHLPPEQILKVSSGETDPTWVGAWWLSFIAASFVGFVAVLPLAS 355

  Fly   429 FPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQ-----SQAPPKVD 488
            .||||. ...|..:|.:....:.|..|........|..|...:.:.....:|     |..|.:
Worm   356 LPKVLP-ASLKWHRSRLHDAAVANRRRTPECCGMPGSNKTAALNSDAPMAEQASLLYSSIPAR-- 417

  Fly   489 TGYGK-------DIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQ 546
             |.|.       |::.||.::.|::.|.::::......::.::|:|...|:.||||.|||:..|:
Worm   418 -GRGPLWYKIWLDVRHIPIAIYRILTNWLFMIITSAMAIDSLVVTGASSFMSKYLERQFSVRPSK 481

  Fly   547 ANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLA-CYAMLFFLGCDNLKMAG 610
            ||:..|.:.||.|.:|..:.|.|:..|:|.....::|.:  .:|.|: .::.::.:.|.:..:.|
Worm   482 ANLLIGCVMVPMAGMGCMVTGGIVNHFRLNSSKMLKFAI--GLIFLSLLFSPMYLIYCPHAPLVG 544

  Fly   611 T---------TIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCG--NNG--LTYFSP 662
            .         :||.|    :.:..:.|..:|   :||..|.|..||..|||.  ::|  .||:||
Worm   545 VDSAYPEFDGSIPDY----NATYSKDPELMN---SCNKQCTCDPSEYRPVCAELDDGRQFTYYSP 602

  Fly   663 CHAGCTAFSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVP-VATAGPCAT 726
            |:|||:...|.|...||.|:||..|..:.                         | :...|.|..
Worm   603 CYAGCSETYSASLKEYTECSCVPTNTKNR-------------------------PRIVKKGVCEP 642

  Fly   727 PCRTIYPFLIL---LFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILF 788
            .|..:..||:|   |.|.||.:|   :|::.::||:|...|||||||:|:::.|:.|.||||:||
Worm   643 QCTELLWFLLLFAPLSFCTFAIA---VPIISVILRTVDYNERSFALGIQWIMIRVIGTIPAPVLF 704

  Fly   789 GNLIDSTCILWKS-SCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMV 839
            |.:.|.:||.::| |||...|.||:|..:.....::....|.::|.|.|.:|
Worm   705 GWMFDVSCIKYQSDSCGSSSGGCLMYSNQYLANLFLTFTISGQIITLAILIV 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	206/688 (30%)
		MFS	174..>433	CDD:119392	86/269 (32%)
		MFS	512..>600	CDD:304372	25/88 (28%)
		KAZAL_SLC21	633..684	CDD:238650	23/54 (43%)
F53B1.8	NP_001294793.1	oat	72..763	CDD:273279	217/743 (29%)
		MFS	105..>360	CDD:119392	86/271 (32%)
		KAZAL_SLC21	569..625	CDD:238650	25/58 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720