DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco4a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_598292.2	Gene:	Slco4a1 / 171144	RGDID:	620228	Length:	723	Species:	Rattus norvegicus

Alignment Length:	822	Identity:	256/822 - (31%)
Similarity:	390/822 - (47%)	Gaps:	153/822 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LYSETNSGDDSSIDAALDHDSQPHATSYLAGDQLPSTVGSGPGG-GGPSAVADSVTVKCHSRQAS 131
            |::.|:|..||..      |:.|.:.:      .|:::.|..|. |..|.......|:..|.||:
  Rat    18 LFTSTSSTTDSGC------DTPPSSRA------SPASLRSAHGALGSSSQPLFEPQVEKRSSQAA 70

  Fly   132 AGKCPADPEEDFDEEQFRSGD-----CGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYI 191
            .            |.|:.|..     ||..:..|..:|.|...|.|:..|.....:|....:|:|
  Rat    71 R------------EVQYLSSGPQSTLCGWQSFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFI 123

  Fly   192 NSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMV 256
            |:|||:||:||::.|..||||||||:|...:.:.||||.|...|.|.|:|.||:::|||||||.:
  Rat   124 NTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFAL 188

  Fly   257 PHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHT---LREDNCLEGKAS 318
            ||||.                             ||....:.::.|...|   |...:.:|.|..
  Rat   189 PHFTA-----------------------------GRYEVEIDDEGLGTETGTCLTNQSQVECKDR 224

  Fly   319 TTGPV---LLFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGA 380
            .:|..   |:|:|.|||.|.|.:||:|||.||:|::|::..|.:||...|:....||..|:|:|.
  Rat   225 ASGLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGG 289

  Fly   381 YLLSFHMDSLSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSV 445
            .:|:.:.:....|  .:|.....|||.||.|||..|:...::|:|...:|:
  Rat   290 AMLNVYTEVGQRT--ELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPR-------------- 338

  Fly   446 VQPVLPNNSRATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPV 510
               .||.:.|..|          :........:|.|:..|    .:||.::|:|.|:..|::||.
  Rat   339 ---QLPGSQRYVV----------MRAAETQQLKDHSRDNP----AFGKTVRDLPLSVWILLRNPT 386

  Fly   511 YIVTCLGACMELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQL 575
            :|:.||....|..:::|...|.||:.|.||||..|:|....|.:.||....|..|||.::.:|:|
  Rat   387 FILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKL 451

  Fly   576 KPKGAVQFVLITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFG 640
            :..|.::|.|...:..|..: .:|.:.|.|:.|||.|..|.     ||.|.:. |::|.||||..
  Rat   452 RGSGIIRFCLFCTLTSLLAF-FVFLMHCPNVHMAGVTTGYV-----GSLLPKG-QLDLKAACNAL 509

  Fly   641 CECLTSEVEPVCGNNGLTYFSPCHAGCTAFSST---SNTNYTNCACVRANISSSIYRGAGGSQAQ 702
            ..|......|:||::|..|:|||:|||...:.|   ....|..|:|:....||    |.|.
  Rat   510 YCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRGCSCILEKASS----GWGN---- 566

  Fly   703 ALSANENFAEVTVVPVATAGPCATPCRTIYPFLILLFFM----TFLVASTQMPLLMIVLRSVSEE 763
                            ||||.||:.|:: .|.|::|.|:    |||   :.:|.|...||.|.:.
  Rat   567 ----------------ATAGKCASTCQS-KPLLLVLVFVVIIFTFL---SSIPALTATLRCVCDR 611

  Fly   764 ERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKF-RYKYV-GLC 826
            :||||||:|:::.|..|.||.||.||.:||..|:||:..||.:|. |.:|..|.. ||..: ||
  Rat   612 QRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGS-CFVYKNEAMSRYLLIAGL- 674

  Fly   827 ASVKLIALVIFMVDWWLVRRRKQLEKMKPLNASDPIIGSIIS 868
             :.|::..:.|:..::|.:        .|..:||.:..|:.|
  Rat   675 -TFKVLGFLFFVAAYFLYK--------SPSVSSDGLEASLPS 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	219/659 (33%)
		MFS	174..>433	CDD:119392	93/264 (35%)
		MFS	512..>600	CDD:304372	28/87 (32%)
		KAZAL_SLC21	633..684	CDD:238650	20/53 (38%)
Slco4a1	NP_598292.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..57		10/45 (22%)
		OATP	103..665	CDD:281175	219/659 (33%)
		MFS	105..>340	CDD:119392	93/282 (33%)
		KAZAL_SLC21	502..556	CDD:238650	20/53 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820