DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco6b1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_596903.1	Gene:	Slco6b1 / 170925	RGDID:	620278	Length:	748	Species:	Rattus norvegicus

Alignment Length:	840	Identity:	212/840 - (25%)
Similarity:	352/840 - (41%)	Gaps:	175/840 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 AGTANRKGHRRQESMYQMTGLYSETNSGDDSSIDAALDHDSQPHATSYLAGDQLPSTVGSGPGGG 112
            |.||..:.....|:...:|     |.:..|.:.:|.:|..:|                  .|...
  Rat    10 ASTAKARKDNTLEAPVNIT-----TEAPVDITTEAPVDITAQ------------------APVDI 51

  Fly   113 GPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFR------------SGDCGILNCR------ 159
            ...|:||   :...:...|:.:.|.:...|.|:|..|            |...|:.|..
  Rat    52 TAEALAD---ITAEAWMDSSAEPPKEEWTDDDQEHIRVFPYQIRLSAAMSDVTGLQNANSETSSQ 113

  Fly   160 -----------PYG--------IQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIP 205
                       |:|        :|||..|..|::...:|. :.|.:..|..:..|...|:.|.:.
  Rat   114 LSDKIPTDLDGPFGLGSLVVPSLQRFNNINFFLISFCILT-LAQGIVFGLTDLSIGNFERDFYLS 177

  Fly   206 SSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIV 270
            .....|:.::|::.:::.||.|::.|.|.....|:...|.::|:||::..:|:...|.   |..|
  Rat   178 HPEKILLTTAYDLSSLLVVIIVAHYGGRGRRSRWVATAAFLVGLGSIIGALPYLKYEV---IHPV 239

  Fly   271 NKTSDNICKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGC 335
            .:|.: :||     |::            |...|      ||.:.....:..:.|.|:.|...|.
  Rat   240 EETGE-LCK-----DEE------------QRTMP------NCEKIIPFKSEIIYLSVIGQCFQGF 280

  Fly   336 GGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLS-STTISITP 399
            ...|::.||.||:.|::.:..:.:|:|...:....|..:|:.:|:..|   ..||: |:...:..
  Rat   281 ASMPMYVLGMTYIYDNISSYLAGIYLGIADASFVLGYGLGYAVGSPNL---RPSLNHSSEEKVND 342

  Fly   400 GDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATV-ATDEM 463
            ....|...|:.||....::......|...||.                 .||.:::..| ..:|.
  Rat   343 NFLWWQFNWFLGFFSATLLAWFTVFPLLCFPH-----------------RLPGSNKLRVWKENEP 390

  Fly   464 GKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGAC--MELMIVS 526
            ...||.:                 |..||...:|:.:::..|||||  ::.|...|  .|.:.:.
  Rat   391 FFYKKYK-----------------DLKYGYSFQDLLRALWYLVKNP--LLMCYSMCKATESLALI 436

  Fly   527 GFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVIC 591
            |...|||||||.||.|..|.|.:.||.|.:||..||.||||.|:.:.::..|..::|:.:|:||.
  Rat   437 GATEFLPKYLENQFLLSPSSAALLTGIILIPGGAIGNFLGGFIVSKMKMSCKTQMRFITVTSVIS 501

  Fly   592 LACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNG 656
            |..:.:..|:.|:.:|.||....|..|...|         ||||.||..|.|.:.....:||.:.
  Rat   502 LLLFVLNAFVKCERVKFAGINSDYEGSGTLG---------NLTAPCNAHCGCTSHTYYAICGRDE 557

  Fly   657 LTYFSPCHAGCTAFSSTSNTNYT----NCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVP 717
            :.|||||.|||.   ::...||.    ||:|::..:            |.|.|.|:        |
  Rat   558 IEYFSPCFAGCL---NSKELNYEKTLYNCSCIKHGL------------ANADSEND--------P 599

  Fly   718 V-ATAGPCATPCRTIYPFLILLFFMTFLVAST-QMPLLMIVLRSVSEEERSFALGMQFVIFRLFG 780
            : |..|.|.|.|..: |.....||.:.:.:|: .:|:.:|:||::.....|..|.:.:.|.|:||
  Rat   600 IDAFLGKCNTKCYAL-PLFFAFFFSSIVFSSSASIPITLIILRTLPTSLHSLGLAVTYTILRIFG 663

  Fly   781 YIPAPILFGNLIDSTCILWK-SSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMV 839
            .||.|:||.....|:|..|. :.||.: |.|.||:..|.....:|||.|.|||:.::.::
  Rat   664 SIPGPLLFRIASSSSCSYWDINKCGLR-GHCWIYNKFKMMSILMGLCISCKLISTLLSLL 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	175/657 (27%)
		MFS	174..>433	CDD:119392	56/259 (22%)
		MFS	512..>600	CDD:304372	34/89 (38%)
		KAZAL_SLC21	633..684	CDD:238650	21/54 (39%)
Slco6b1	NP_596903.1	OATP	144..701	CDD:281175	175/657 (27%)
		MFS	146..>510	CDD:119392	105/430 (24%)
		KAZAL_SLC21	534..587	CDD:238650	22/55 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820