DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and Slco3a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_803434.1	Gene:	Slco3a1 / 140915	RGDID:	620227	Length:	710	Species:	Rattus norvegicus

Alignment Length:	805	Identity:	267/805 - (33%)
Similarity:	408/805 - (50%)	Gaps:	147/805 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GSGPG---GGGPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGDCGILNCRPYGIQRFA 167
            |..||   |||.|                 |:...| |...::::.:...|            |:
  Rat     3 GKKPGGSSGGGRS-----------------GELQGD-EAQRNKKKKKKVSC------------FS 37

  Fly   168 RIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGS 232
            .||||:| ....:|:.|.....|:.||:||:|:||.:.|:..|:||||:||||:..::||||.|:
  Rat    38 NIKIFLV-SECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGA 101

  Fly   233 RRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSGL 297
            |.|.|..||.|.::|.:|:|:..:|.|                      |......:.|.:..|.
  Rat   102 RGHRPRLIGCGGIVMALGALLSALPEF----------------------LTHQYKYEAGEIRWGA 144

  Fly   298 SNQPLAPHTLREDNC-LEGKASTTGP---------------VLLFVLAQLLLGCGGSPLFTLGTT 346
            ..:         |.| ..|.:|..||               .||.:.||:|||.|.:|:..||.:
  Rat   145 EGR---------DVCATNGSSSDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVS 200

  Fly   347 YVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS--LSSTTISITPGDRRWVGMWW 409
            |:|||||.:.||:|||.:::|..|||..||:||::....::|:  :.::.:.|||.|.||:|.||
  Rat   201 YIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWW 265

  Fly   410 GGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAV 474
            |||||||.:|...::..|.||:.|....:...:|.  |.:||..        |..:.|....|..
  Rat   266 GGFLLCGALLFFSSLLMFGFPQSLPPHSEPGMESE--QAMLPER--------EYERPKPSNGVLR 320

  Fly   475 TSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQ 539
            ...|..|.|      ...:.::.||:....|:.|||:....|.||||:.:|:||..||.||||.|
  Rat   321 HPLEPDSSA------SCFQQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQ 379

  Fly   540 FSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCD 604
            |:|..|.||...|..|:|.||:||||||.::|:..|...||::..::.|::..|||....|||||
  Rat   380 FNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCD 444

  Fly   605 NLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTA 669
            .:.:||.|:.|..::..||.|: |:     :.||..|||.|....||||.:|:||.|.|.|||
  Rat   445 TVPVAGVTVRYGNNSARGSPLD-PY-----SPCNNNCECQTDSFTPVCGADGITYLSACFAGC-- 501

  Fly   670 FSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAGPCATP-CRTIY- 732
                ::||.|.|||:                  .....||   .||||    |.|.:| |:..:
  Rat   502 ----NSTNLTGCACL------------------TTVPPEN---ATVVP----GKCPSPGCQEAFL 537

  Fly   733 PFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLIDSTCI 797
            .||.::...:.:.|..|.|.::|::|:||.|.:|:|||:.|::.||.|:||.|::||..|||||:
  Rat   538 TFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDSTCL 602

  Fly   798 LWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRR--RKQLEKMKPLNASD 860
            .|.:.|||:|. |::||...:||.||.:..::|..|.:::...|..:|:  ::.::..:...::.
  Rat   603 FWSTFCGEQGA-CVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGGLSTS 666

  Fly   861 PIIGSIISLDKLFEEKLSGAEPSTA 885
            ..:.|.::||.|      |.:|..|
  Rat   667 EFLASTLTLDNL------GRDPVPA 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	238/666 (36%)
		MFS	174..>433	CDD:119392	97/276 (35%)
		MFS	512..>600	CDD:304372	39/87 (45%)
		KAZAL_SLC21	633..684	CDD:238650	23/50 (46%)
Slco3a1	NP_803434.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		10/39 (26%)
		OATP	41..619	CDD:281175	237/663 (36%)
		MFS	47..>286	CDD:119392	94/269 (35%)
		KAZAL_SLC21	467..511	CDD:238650	23/54 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770