Protein Alignment Oatp30B and SLCO2B1

DIOPT Version :10

• Sequence 1: NP_609293.2
• Gene: Oatp30B / 34268
• FlyBaseID: FBgn0032123
• Length: 1197
• Species: Drosophila melanogaster
• Sequence 2: XP_016872646.2
• Gene: SLCO2B1 / 11309
• HGNCID: 10962
• Length: 733
• Species: Homo sapiens
• Alignment Length: 797
• Identity: 245/797 - (30%)
• Similarity: 385/797 - (48%)
• Gaps: 114/797 - (14%)

  Fly    88 SQPHATSYLAGDQLPSTVGSGPGGGGPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGD 152
            |||:.|..|.  ::...:..||.|..|............:.....||...||::
Human    12 SQPYFTQSLL--KMKMEMEMGPAGEVPQVPDKETKATMGTENTPGGKASPDPQD----------- 63

  Fly   153 CGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYE 217
                 .||   ..|..||:||:..||| .:.|.:.|||:.|.|:|:||||.:.|..|||:||..|
Human    64 -----VRP---SVFHNIKLFVLCHSLL-QLAQLMISGYLKSSISTVEKRFGLSSQTSGLLASFNE 119

  Fly   218 IGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSAL 282
            :||...::||||.|||.|.|..||.||:::.:..|:..:|||..||        ...||.....:
Human   120 VGNTALIVFVSYFGSRVHRPRMIGYGAILVALAGLLMTLPHFISEP--------YRYDNTSPEDM 176

  Fly   283 VRDQDMDL-----GRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLAQLLLGCGGSPLFT 342
            .:|....|     ...:|..||...:.:|..:...:.|        ::|| ||.|||.||.|:..
Human   177 PQDFKASLCLPTTSAPASAPSNGNCSSYTETQHLSVVG--------IMFV-AQTLLGVGGVPIQP 232

  Fly   343 LGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMD--SLSSTTISITPGDRRWV 405
            .|.:|:||.....:|.:|:|.::::...||.:.|.||:.:|..::|  .:....||:|..|.|||
Human   233 FGISYIDDFAHNSNSPLYLGILFAVTMMGPGLAFGLGSLMLRLYVDINQMPEGGISLTIKDPRWV 297

  Fly   406 GMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLE 470
            |.||.|||:....:.:.|:|:|.|||.:.:||::::....|..|  .:|.|....|...|....|
Human   298 GAWWLGFLIAAGAVALAAIPYFFFPKEMPKEKRELQFRRKVLAV--TDSPARKGKDSPSKQSPGE 360

  Fly   471 IVAVTSKED-QSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLG-ACMELMIVSGFVVFLP 533
               .|.|:| ..|..|.:..  .:.||..|:.:|:.:::|::::..|. .|:..| .:|...|||
Human   361 ---STKKQDGLVQIAPNLTV--IQFIKVFPRVLLQTLRHPIFLLVVLSQVCLSSM-AAGMATFLP 419

  Fly   534 KYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAML 598
            |:||.|||:..|.||:..|.::.|...:||.:||.::||..|.|.|.....|:..::||.....|
Human   420 KFLERQFSITASYANLLIGCLSFPSVIVGIVVGGVLVKRLHLGPVGCGALCLLGMLLCLFFSLPL 484

  Fly   599 FFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCG-NNGLTYFSP 662
            ||:||.:.::||.|  :.||...|        :.|:.:|...|.|......|||. :..:.|.:|
Human   485 FFIGCSSHQIAGIT--HQTSAHPG--------LELSPSCMEACSCPLDGFNPVCDPSTRVEYITP 539

  Fly   663 CHAGCTAF-----SSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATAG 722
            |||||:::     ...|...||||:||                   :..|         || .||
Human   540 CHAGCSSWVVQDALDNSQVFYTNCSCV-------------------VEGN---------PV-LAG 575

  Fly   723 PCATPC-RTIYPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPI 786
            .|.:.| ..:.|||:|:...:.|...|..|..|::||.|.:|:::.|:|:||:..|:..::|:|:
Human   576 SCDSTCSHLVVPFLLLVSLGSALACLTHTPSFMLILRGVKKEDKTLAVGIQFMFLRILAWMPSPV 640

  Fly   787 LFGNLIDSTCILWKSSCGEKGGRCLIYDIEKFRYKYVGL-----CASVKLIALVIFMVDWWLVRR 846
            :.|:.||:||:.|..|||.: ..|..|:.:..|.:::||     ..||...|||:      .|.|
Human   641 IHGSAIDTTCVHWALSCGRR-AVCRYYNNDLLRNRFIGLQFFFKTGSVICFALVL------AVLR 698

  Fly   847 RKQLEKMKPLNASDPII 863
            ::..|.....:.|.|.:
Human   699 QQDKEARTKESRSSPAV 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	MFS_SLCO5_OATP5	170..758	CDD:340962	193/603 (32%)
		UhpC	<730..795	CDD:441872	22/64 (34%)
SLCO2B1	XP_016872646.2	MFS_SLCO2B_OATP2B	72..612	CDD:341018	194/604 (32%)