DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco3a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_076397.2	Gene:	Slco3a1 / 108116	MGIID:	1351867	Length:	710	Species:	Mus musculus

Alignment Length:	809	Identity:	265/809 - (32%)
Similarity:	403/809 - (49%)	Gaps:	155/809 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GSGPG---GGGPSAVADSVTVKCHSRQASAGKCPADPEEDFDEEQFRSGDCGILNCRPYGIQRFA 167
            |..||   |||.|                 |:...| |...::::.:...|            |:
Mouse     3 GKKPGGSSGGGRS-----------------GELQGD-EAQRNKKKKKKVSC------------FS 37

  Fly   168 RIKIFVVLLSLLVMMQQALSSGYINSVITTIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGS 232
            .||||:| ....:|:.|.....|:.||:||:|:||.:.|:..|:||||:||||:..::||||.|:
Mouse    38 NIKIFLV-SECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGA 101

  Fly   233 RRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSGL 297
            |.|.|..||.|.::|.:|:|:..:|.|                      |......:.|.:..|.
Mouse   102 RGHRPRLIGCGGIVMALGALLSALPEF----------------------LTHQYKYEAGEIRWGA 144

  Fly   298 SNQPLAPHTLREDNC-LEGKASTTGP---------------VLLFVLAQLLLGCGGSPLFTLGTT 346
            ..:         |.| ..|.:|..||               .||.:.||:|||.|.:|:..||.:
Mouse   145 EGR---------DVCATNGSSSDEGPDPDLICRNRTATNMMYLLLIGAQVLLGIGATPVQPLGVS 200

  Fly   347 YVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS--LSSTTISITPGDRRWVGMWW 409
            |:|||||.:.||:|||.:::|..|||..||:||::....::|:  :.::.:.|||.|.||:|.||
Mouse   201 YIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWW 265

  Fly   410 GGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATVATDEMGKVKKLEIVAV 474
            |||||||.:|...::..|.||:.|........:|.  |.:||..        |..:.|....|..
Mouse   266 GGFLLCGALLFFSSLLMFGFPQSLPPHSDPGMESE--QAMLPER--------EYERPKPSNGVLR 320

  Fly   475 TSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELMIVSGFVVFLPKYLETQ 539
            ...|..|.|      ...:.::.||:....|:.|||:....|.||||:.:|:||..||.||||.|
Mouse   321 HPLEPDSSA------SCFQQLRVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQ 379

  Fly   540 FSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITNVICLACYAMLFFLGCD 604
            |:|..|.||...|..|:|.||:||||||.::|:..|...||::..::.|::..|||....|||||
Mouse   380 FNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLFLGCD 444

  Fly   605 NLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCGNNGLTYFSPCHAGCTA 669
            ...:||.|:.|..::..||.|: |:     :.||..|||.|....||||.:|:||.|.|.|||
Mouse   445 TGPVAGVTVRYGNNSARGSALD-PY-----SPCNNNCECQTDSFTPVCGADGITYLSACFAGC-- 501

  Fly   670 FSSTSNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTVVPVATA----GPCATP-CR 729
                ::||.|.|||                             :|.||...|    |.|.:| |:
Mouse   502 ----NSTNLTGCAC-----------------------------LTTVPPENASVVPGKCPSPGCQ 533

  Fly   730 TIY-PFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVIFRLFGYIPAPILFGNLID 793
            ..: .||.::...:.:.|..|.|.::|::|:||.|.:|:|||:.|::.||.|:||.|::||..||
Mouse   534 EAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGID 598

  Fly   794 STCILWKSSCGEKGGRCLIYDIEKFRYKYVGLCASVKLIALVIFMVDWWLVRR--RKQLEKMKPL 856
            |||:.|.:.|||:|. |::||...:||.||.:..::|..|.:::...|..:|:  ::.::..:..
Mouse   599 STCLFWSTFCGEQGA-CVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHEGG 662

  Fly   857 NASDPIIGSIISLDKLFEEKLSGAEPSTA 885
            .::.....|.::||.|      |.:|..|
Mouse   663 LSTSEFFASTLTLDNL------GRDPVPA 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	236/670 (35%)
		MFS	174..>433	CDD:119392	97/276 (35%)
		MFS	512..>600	CDD:304372	39/87 (45%)
		KAZAL_SLC21	633..684	CDD:238650	23/50 (46%)
Slco3a1	NP_076397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25		10/39 (26%)
Slco3a1	NP_076397.2	MFS_SLCO3_OATP3	39..563	CDD:340960	208/612 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5914
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3818
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.750