DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp30B and Slco4a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001342147.1	Gene:	Slco4a1 / 108115	MGIID:	1351866	Length:	723	Species:	Mus musculus

Alignment Length:	813	Identity:	257/813 - (31%)
Similarity:	393/813 - (48%)	Gaps:	135/813 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LYSETNSGDDSSIDAALDHDSQPHATSYLAGDQLPSTVGSGPGG-GGPSAVADSVTVKCHSRQAS 131
            |::.|:|..||..|......:.|.:.....|     |:||.... ..|.|...|.......:..|
Mouse    18 LFTSTSSATDSGCDTPPSSRASPASLRSAHG-----TLGSSSQPLFEPQAEKRSSQTAREVQYVS 77

  Fly   132 AGKCPADPEEDFDEEQFRSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVIT 196
            :|     |:...         ||.....|..:|.|...|.|:..|.....:|....:|:||:|||
Mouse    78 SG-----PQNSL---------CGWQAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVIT 128

  Fly   197 TIEKRFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTG 261
            :||:||::.|..||||||||:|...:.:.||||.|...|.|.|:|.|.:::|||||||.:||||
Mouse   129 SIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFT- 192

  Fly   262 EPNPGIAIVNKTSDNICKSALVRDQDMDLGRLSSG--LSNQPLAPHTLREDNCLEGKASTTGPVL 324
                               |...:.:||.| |.:|  |:||   .|.    .|.:..:..:...|
Mouse   193 -------------------AGRYEVEMDEG-LGTGTCLTNQ---SHV----ECKDSASGLSNYRL 230

  Fly   325 LFVLAQLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDS 389
            :|:|.|||.|.|.:||:|||.||:|::|::..|.:||...|:....||..|:|:|..:|:.:.:.
Mouse   231 IFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEV 295

  Fly   390 LSSTTISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNS 454
            ...|  .:|.....|||.||.|||..|:...::|:|...:|:.|...::.:...:.....|.::|
Mouse   296 GQRT--ELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHS 358

  Fly   455 RATVATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGAC 519
            |..|:                            :..:||.::|:|.|:..|::||.:|:.||...
Mouse   359 RGAVS----------------------------NPAFGKTVRDLPLSIWLLLRNPTFILLCLAGA 395

  Fly   520 MELMIVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFV 584
            .|..:::|...|.||:.|.||||..|:|....|.:.||....|..|||.::.:|:|:..|.::|.
Mouse   396 TEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFC 460

  Fly   585 LITNVICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVE 649
            |...:..|..: .:|.:.|.|:.|||.|..|.     ||.|.:. |::|.||||....|......
Mouse   461 LFCTLTSLLAF-FVFLMHCPNVHMAGVTTGYV-----GSLLPKG-QLDLKAACNAIYCCQPKHYS 518

  Fly   650 PVCGNNGLTYFSPCHAGCTAFSST---SNTNYTNCACVRANISSSIYRGAGGSQAQALSANENFA 711
            |:||::|..|:|||:|||.|.:.|   ....|..|:|:....||    |.|.
Mouse   519 PLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASS----GWGN------------- 566

  Fly   712 EVTVVPVATAGPCATPCRTIYPFLILLFFM----TFLVASTQMPLLMIVLRSVSEEERSFALGMQ 772
                   ||||.||:.|:: .|||::|.|:    |||   :.:|.|...||.||:.:||||||:|
Mouse   567 -------ATAGKCASTCQS-KPFLLVLVFVVIIFTFL---SSIPALTATLRCVSDRQRSFALGIQ 620

  Fly   773 FVIFRLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIYDIEKF-RYKYV-GLCASVKLIALV 835
            :::.|..|.||.||.||.:||..|:||:..||.:|. |.:|:.|.. ||..: ||  :.|::..:
Mouse   621 WIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGS-CFVYENEAMSRYMLIAGL--TFKVLGFL 682

  Fly   836 IFMVDWWLVRRRKQLEKMKPLNASDPIIGSIIS 868
            .|:..::|.:        .|..:||.:..|:.|
Mouse   683 FFVAAYFLYK--------SPSVSSDGLEASLPS 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	222/655 (34%)
		MFS	174..>433	CDD:119392	95/260 (37%)
		MFS	512..>600	CDD:304372	28/87 (32%)
		KAZAL_SLC21	633..684	CDD:238650	21/53 (40%)
Slco4a1	NP_001342147.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..64		11/45 (24%)
		OATP	103..665	CDD:308646	222/655 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..723		2/8 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3626
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101062
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720