DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Oatp30B and slco4a1

DIOPT Version :9

Sequence 1:	NP_609293.2	Gene:	Oatp30B / 34268	FlyBaseID:	FBgn0032123	Length:	1197	Species:	Drosophila melanogaster
Sequence 2:	NP_001120155.1	Gene:	slco4a1 / 100145193	XenbaseID:	XB-GENE-5905026	Length:	709	Species:	Xenopus tropicalis

Alignment Length:	778	Identity:	260/778 - (33%)
Similarity:	368/778 - (47%)	Gaps:	164/778 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 EEDFDEEQF----RSGDCGILNCRPYGIQRFARIKIFVVLLSLLVMMQQALSSGYINSVITTIEK 200
            |.|..|.:|    |...||.....|..:|.|...|..:|.|.....:|....:|::|:||||||:
Frog    62 ENDAREIKFVPSERENRCGWGLLTPKCLQVFNNPKGVLVFLCAASFLQGMTVNGFLNTVITTIER 126

  Fly   201 RFEIPSSYSGLIASSYEIGNVITVIFVSYLGSRRHIPVWIGIGAVIMGIGSLVFMVPHFTGEPNP 265
            ||.:.|.::|||||||:|...:.:.||||.|...|.|.|:|.|..||||||.:|.:|||:.:...
Frog   127 RFYLRSYHTGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVFIMGIGSFIFALPHFSNDSYE 191

  Fly   266 GIAIVNKTSDNI-CKSALVRDQDMDLGRLSSGLSNQPLAPHTLREDNCLEGKASTTGPVLLFVLA 329
                :|...|.. |:|    ::...|...:|.|||..                      .:|:|.
Frog   192 ----INFNFDTEGCRS----NRTQQLPESASSLSNYR----------------------FVFMLG 226

  Fly   330 QLLLGCGGSPLFTLGTTYVDDHVRTESSSMYIGFMYSMGAFGPVVGFLLGAYLLSFHMDSLSSTT 394
            |.|.|.|.:||:|||.||:|::|::.:|.:|||..|:....||.||:|||.:.|:.:.|....|
Frog   227 QFLHGIGATPLYTLGVTYLDENVKSSNSPVYIGIFYTAAIVGPAVGYLLGGFFLNIYTDISRQT- 290

  Fly   395 ISITPGDRRWVGMWWGGFLLCGVILLVVAVPFFSFPKVLAREKKKIRKSSVVQPVLPNNSRATV- 458
             .:|||:..|||.||.|||..||...::::|..::|:                 .||.:.|..|
Frog   291 -DLTPGNPLWVGAWWIGFLAAGVAGFLISLPILAYPQ-----------------QLPGSQRYMVM 337

  Fly   459 ATDEMGKVKKLEIVAVTSKEDQSQAPPKVDTGYGKDIKDIPQSMLRLVKNPVYIVTCLGACMELM 523
            ...|..:||..:.:.              |..:||.|||:|:|:|.|:|||.::..||....|..
Frog   338 RVSEAHQVKDSDSIK--------------DPEFGKTIKDLPKSLLMLLKNPTFVFLCLAGATEAT 388

  Fly   524 IVSGFVVFLPKYLETQFSLGKSQANIFTGSIAVPGACIGIFLGGCILKRFQLKPKGAVQFVLITN 588
            :::|...|.||:||:||||..|||....|.:.||....|.||||.|:.:.:|....|::|.:|..
Frog   389 LITGMSTFGPKFLESQFSLSASQAATCFGYLVVPAGGGGTFLGGFIVNKLKLNCSAAIKFCVICT 453

  Fly   589 VICLACYAMLFFLGCDNLKMAGTTIPYYTSNKHGSTLEQPFQVNLTAACNFGCECLTSEVEPVCG 653
            ||.|.. ..:|.|.|.||::.|...||     ..|.|.:..| ||||.||..|.||.....|||.
Frog   454 VIGLLS-MFVFLLSCPNLELVGVNAPY-----RESVLLEGSQ-NLTALCNADCRCLEEIYSPVCV 511

  Fly   654 NNGLTYFSPCHAGCT-AFSSTSNTN--YTNCACVRANISSSIYRGAGGSQAQALSANENFAEVTV 715
            ...:||:|.|||||: |:|...|..  |.||:||           ||.
Frog   512 EGNITYYSACHAGCSEAYSDIRNDQKVYQNCSCV-----------AGA----------------- 548

  Fly   716 VPVATAGPCATPCRTI-----YPFLILLFFMTFLVASTQMPLLMIVLRSVSEEERSFALGMQFVI 775
              |..||.|.:||.|:     :.||::||  |||.:   :|.|...||.||:.:||||||:|:::
Frog   549 --VVVAGKCLSPCNTMPLLLAFVFLVILF--TFLCS---VPALTATLRCVSDNQRSFALGIQWIL 606

  Fly   776 FRLFGYIPAPILFGNLIDSTCILWKSSCGEKGGRCLIY---DIEKFR------YKYVGLCASVKL 831
            .|..|.||.||.||::||.:|:.|:.. |...|.|..|   |:..:.      ||.:||.  ..|
Frog   607 ARALGAIPGPIAFGSMIDISCLRWQKQ-GGANGSCYFYQNSDMSNYMLMAGLVYKVLGLL--FFL 668

  Fly   832 IALVIFMVDWWLVRRRKQLEKMKPLNASDPIIGSIISLDKLFEEKLSGAEPSTAFVGGGGELI 894
            .||.::              |..||:.                   ||.:..|..:.|..|.|
Frog   669 FALFLY--------------KPPPLSP-------------------SGEQKGTNCIKGNAEEI 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp30B	NP_609293.2	OATP	171..818	CDD:281175	233/659 (35%)
		MFS	174..>433	CDD:119392	96/259 (37%)
		MFS	512..>600	CDD:304372	32/87 (37%)
		KAZAL_SLC21	633..684	CDD:238650	25/53 (47%)
slco4a1	NP_001120155.1	MFS_SLCO4A_OATP4A	95..589	CDD:341020	206/598 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123298at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X98
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010