DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdi and GDI1

DIOPT Version :9

Sequence 1:	NP_001245953.1	Gene:	Gdi / 34264	FlyBaseID:	FBgn0004868	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_011062.1	Gene:	GDI1 / 856876	SGDID:	S000000938	Length:	451	Species:	Saccharomyces cerevisiae

Alignment Length:	433	Identity:	237/433 - (54%)
Similarity:	319/433 - (73%)	Gaps:	8/433 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNEEYDAIVLGTGLKECILSGMLSVSGKKVLHIDRNKYYGGESASITPLEELFQRYGLEPPGE-- 63
            ::.:||.||||||:.||||||:|||.||||||||:..:||||:||:| |.:|::::...|..:
Yeast     6 IDTDYDVIVLGTGITECILSGLLSVDGKKVLHIDKQDHYGGEAASVT-LSQLYEKFKQNPISKEE 69

  Fly    64 ---RFGRGRDWNVDLIPKFLMANGQLVKLLIHTGVTRYLEFKSIEGSYVYKGGKIAKVPVDQKEA 125
               :||:.||||||||||||||||:|..:||||.||||::||.:.||||:|.|||.|||.::.||
Yeast    70 RESKFGKDRDWNVDLIPKFLMANGELTNILIHTDVTRYVDFKQVSGSYVFKQGKIYKVPANEIEA 134

  Fly   126 LASDLMGMFEKRRFRNFLIYVQDFREDDPKTWKDFDPTKANMQGLYDKFGLDKNTQDFTGHALAL 190
            ::|.|||:|||||.:.||.::..::|||..|.:..|..|..|..:|.||||..:|::|.|||:||
Yeast   135 ISSPLMGIFEKRRMKKFLEWISSYKEDDLSTHQGLDLDKNTMDEVYYKFGLGNSTKEFIGHAMAL 199

  Fly   191 FRDDEYLNEPAVNTIRRIKLYSDSLARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDKPID 255
            :.:|:||.:||..:..||.||..|:||||||||||||||||||||||||||||||||||||.|||
Yeast   200 WTNDDYLQQPARPSFERILLYCQSVARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDTPID 264

  Fly   256 EIVL-GEGGKVVGVRSGEEVAKCKQVYCDPSYVPEKVRKRG-KVIRCICILDHPVASTKDGLSTQ 318
            |::. .:.||..||::.....|...|..||:|.|||.:..| :|||.||||:|||.:|.:..|.|
Yeast   265 EVLYKKDTGKFEGVKTKLGTFKAPLVIADPTYFPEKCKSTGQRVIRAICILNHPVPNTSNADSLQ 329

  Fly   319 IIIPQKQVGRKSDIYVSLVSSTHQVAAKGWFVGMVSTTVETENPEVEIKPGLDLLEPIAQKFVTI 383
            |||||.|:||||||||::||..|.|.:||.::.::||.:||:.|.:|::|...||.||.:||:.|
Yeast   330 IIIPQSQLGRKSDIYVAIVSDAHNVCSKGHYLAIISTIIETDKPHIELEPAFKLLGPIEEKFMGI 394

  Fly   384 SDYLEPIDDGSESQIFISESYDATTHFETTCLDVLNIFKRGTG 426
            ::..||.:|||:..|::|.||||::|||:...||.:|:.|.||
Yeast   395 AELFEPREDGSKDNIYLSRSYDASSHFESMTDDVKDIYFRVTG 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdi	NP_001245953.1	GDI	1..435	CDD:279353	237/433 (55%)
GDI1	NP_011062.1	GDI	1..447	CDD:395792	237/433 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344514
Domainoid	1	1.000	459	1.000	Domainoid score	I60
eggNOG	1	0.900	-	-		E1_COG5044
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37487
Inparanoid	1	1.050	478	1.000	Inparanoid score	I223
Isobase	1	0.950	-	0.930827	Normalized mean entropy	S274
OMA	1	1.010	-	-		QHG53557
OrthoFinder	1	1.000	-	-		FOG0001483
OrthoInspector	1	1.000	-	-		oto99424
orthoMCL	1	0.900	-	-		OOG6_100967
Panther	1	1.100	-	-	LDO	PTHR11787
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R485
SonicParanoid	1	1.000	-	-		X942
TreeFam	1	0.960	-	-
	16	15.740