DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gdi and Gdi2

DIOPT Version :9

Sequence 1:	NP_001245953.1	Gene:	Gdi / 34264	FlyBaseID:	FBgn0004868	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_058972.2	Gene:	Gdi2 / 29662	RGDID:	61802	Length:	445	Species:	Rattus norvegicus

Alignment Length:	442	Identity:	296/442 - (66%)
Similarity:	363/442 - (82%)	Gaps:	4/442 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNEEYDAIVLGTGLKECILSGMLSVSGKKVLHIDRNKYYGGESASITPLEELFQRYGL--EPPGE 63
            ||||||.|||||||.||||||::||:||||||:|:|.|||||||||||||:|::|:.|  :||..
  Rat     1 MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDQNPYYGGESASITPLEDLYKRFKLPGQPPAS 65

  Fly    64 RFGRGRDWNVDLIPKFLMANGQLVKLLIHTGVTRYLEFKSIEGSYVYKGGKIAKVPVDQKEALAS 128
             .|||||||||||||||||||||||:|:.|.||||::||.||||:|||||||.|||..:.|||||
  Rat    66 -MGRGRDWNVDLIPKFLMANGQLVKMLLFTEVTRYMDFKVIEGSFVYKGGKIYKVPSTEAEALAS 129

  Fly   129 DLMGMFEKRRFRNFLIYVQDFREDDPKTWKDFDPTKANMQGLYDKFGLDKNTQDFTGHALALFRD 193
            .|||:|||||||.||:||.:|.|.||:|::..||.|.:|:.:|.||.|.::..|||||:|||:|.
  Rat   130 SLMGLFEKRRFRKFLVYVANFDEKDPRTFEGVDPKKTSMRDVYKKFDLGQDVIDFTGHSLALYRT 194

  Fly   194 DEYLNEPAVNTIRRIKLYSDSLARYGKSPYLYPMYGLGELPQGFARLSAIYGGTYMLDKPIDEIV 258
            |:||::|...||.||||||:|||||||||||||:|||||||||||||||||||||||:|||:||:
  Rat   195 DDYLDQPCCETINRIKLYSESLARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPIEEII 259

  Fly   259 LGEGGKVVGVRSGEEVAKCKQVYCDPSYVPEKVRKRGKVIRCICILDHPVASTKDGLSTQIIIPQ 323
            : :.||||||:|..|:|:|||:.||||||.::|.|.|:|||.||||.||:.:|.|..|.||||||
  Rat   260 V-QNGKVVGVKSEGEIARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTNDANSCQIIIPQ 323

  Fly   324 KQVGRKSDIYVSLVSSTHQVAAKGWFVGMVSTTVETENPEVEIKPGLDLLEPIAQKFVTISDYLE 388
            .||.|||||||.::|..|.|||:|.::.:|||||||:.||.||:|.|:|||||.||||:|||...
  Rat   324 NQVNRKSDIYVCMISFAHNVAAQGKYIAIVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLFV 388

  Fly   389 PIDDGSESQIFISESYDATTHFETTCLDVLNIFKRGTGETFDFSKIKHELGD 440
            |.|.|::||||||.:|||||||||||.|:.:|:||.||..|||.::|.:..|
  Rat   389 PKDLGTDSQIFISRAYDATTHFETTCDDIKDIYKRMTGSEFDFEEMKRKKND 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdi	NP_001245953.1	GDI	1..435	CDD:279353	294/435 (68%)
Gdi2	NP_058972.2	GDI	1..436	CDD:395792	294/436 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344455
Domainoid	1	1.000	616	1.000	Domainoid score	I176
eggNOG	1	0.900	-	-		E1_COG5044
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	619	1.000	Inparanoid score	I849
OMA	1	1.010	-	-		QHG53557
OrthoDB	1	1.010	-	-		D388394at33208
OrthoFinder	1	1.000	-	-		FOG0001483
OrthoInspector	1	1.000	-	-		otm45174
orthoMCL	1	0.900	-	-		OOG6_100967
Panther	1	1.100	-	-	LDO	PTHR11787
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X942
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770