DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gdi and Chm

DIOPT Version :9

Sequence 1:	NP_001245953.1	Gene:	Gdi / 34264	FlyBaseID:	FBgn0004868	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_058763.1	Gene:	Chm / 24942	RGDID:	2340	Length:	650	Species:	Rattus norvegicus

Alignment Length:	555	Identity:	127/555 - (22%)
Similarity:	200/555 - (36%)	Gaps:	207/555 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EYDAIVLGTGLKECILSGMLSVSGKKVLHIDRNKYYGGESASIT--------------------- 47
            ::|.||:||||.|.|::...|.||::|||:|...||||..||.:
  Rat     8 DFDVIVIGTGLPESIIAAACSRSGQRVLHVDSRSYYGGNWASFSFSGLLSWLKEYQENNDVVTEN 72

  Fly    48 --------------PLE---------ELF-----------QRYG--------------------- 57
                          ||.         |:|           :..|
  Rat    73 SMWQEQILENEEAIPLSSKDKTIQHVEVFCYASQDLHKDVEEAGALQKNHASVTSAQSAEAAEAA 137

  Fly    58 --------LEP---------------PG----------ERFGR---------------------- 67
                    :||               ||          |..|:
  Rat   138 ETSCLPTAVEPLSMGSCEIPAEQSQCPGPESSPEVNDAEATGKKENSDAKSSTEEPSENVPKVQD 202

  Fly    68 ------------------GRDWNVDLIPKFLMANGQLVKLLIHTGVTRYLEFKSIEGSYVYKGGK 114
                              ||.:|:||:.:.|.:.|.|:.|||.:.|:||.|||:|.....::.|.
  Rat   203 NTETPKKNRITYSQIIKEGRRFNIDLVSQLLYSRGLLIDLLIKSNVSRYAEFKNITRILAFREGT 267

  Fly   115 IAKVPVDQKEALASDLMGMFEKRRFRNFLIYVQDFREDDPKTWKDFDPTKANMQGLYDKFGLDKN 179
            :.:||..:.:...|..:.|.|||....||.:..:: |:.|..::.::.|..:......|  |..|
  Rat   268 VEQVPCSRADVFNSKQLTMVEKRMLMKFLTFCVEY-EEHPDEYRAYEGTTFSEYLKTQK--LTPN 329

  Fly   180 TQDFTGHALALFRDDEYLNEPAVNTIRRIKLYSDSLARYGKSPYLYPMYGLGELPQGFARLSAIY 244
            .|.|..|::|:..:   .....|:.::..|.:...|.|||.:|:|:|:||.|||||.|.|:.|::
  Rat   330 LQYFVLHSIAMTSE---TTSCTVDGLKATKKFLQCLGRYGNTPFLFPLYGQGELPQCFCRMCAVF 391

  Fly   245 GGTYMLDKPIDEIVLGEGGKVVGVRSGEEVAKCKQV-------------YCDPSYVPEKVRKR-- 294
            ||.|.|...:..:|:           .:|..|||.|             ..:.||:.|....|
  Rat   392 GGIYCLRHSVQCLVV-----------DKESRKCKAVIDQFGQRIISKHFIIEDSYLSENTCSRVQ 445

  Fly   295 -GKVIRCICILDHPVASTKDGLSTQII-IPQKQVGRKSDIYVSLVSSTHQVAAKGWFVGMVS--- 354
             .::.|.:.|.|..|..|.......|: :|.::.|......:.|.||| ....||.::..::
  Rat   446 YRQISRAVLITDGSVLKTDADQQVSILAVPAEEPGSFGVRVIELCSST-MTCMKGTYLVHLTCMS 509

  Fly   355 -------------------TTVETENPEVEIKPGL 370
                               |.:|.||.:|| ||.|
  Rat   510 SKTAREDLERVVQKLFTPYTEIEAENEQVE-KPRL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gdi	NP_001245953.1	GDI	1..435	CDD:279353	127/555 (23%)
Chm	NP_058763.1	NADB_Rossmann	6..530	CDD:304358	118/539 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	156..208		4/51 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..650
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5044
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810