DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment numb and NUMBL

DIOPT Version :9

Sequence 1:NP_001260291.1 Gene:numb / 34263 FlyBaseID:FBgn0002973 Length:556 Species:Drosophila melanogaster
Sequence 2:NP_004747.1 Gene:NUMBL / 9253 HGNCID:8061 Length:609 Species:Homo sapiens


Alignment Length:555 Identity:217/555 - (39%)
Similarity:272/555 - (49%) Gaps:141/555 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 MDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEAL 106
            |::||:|.|   ||:...|||:|:||||||||:|||..||||.|:|||.|||.|||||.|||:|:
Human    42 MNKLRQSLR---RRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAV 103

  Fly   107 KVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRR 171
            |.|:...|:.|:.:|.||.||||||||:||.|:||||||||||||||||.::.||||||||||||
Human   104 KKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRR 168

  Fly   172 WMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFR------- 229
            |:||.|||.||||||||||||||||.||||||||:||||||..||...::|.|.||||       
Human   169 WICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRP 233

  Fly   230 ------QQTLTERLAMATVGTNERSVDGPGSAMPG---PPAATVKP-------------FNPFAI 272
                  .:...|..|..||        .||.|.||   |..||..|             ....||
Human   234 AEREAPDKKKAEAAAAPTV--------APGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAI 290

  Fly   273 ERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRS 335
            .|.||....|.||.|||.....||  ||||||:|||:|:|||...|:..|........|:.|   
Human   291 PRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPP--- 352

  Fly   336 VSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQ 400
                                .|..:||::.||.::|...:         :||             
Human   353 --------------------GAGDSDSINALCTQISSSFA---------SAG------------- 375

  Fly   401 NIIAAEKQVQHVHSYAPPTA----------QVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELP 455
                       ..:..||.|          .|.|..|     :|..|.::||.:|:.:|..:::.
Human   376 -----------APAPGPPPATTGTSAWGEPSVPPAAA-----FQPGHKRTPSEAERWLEEVSQVA 424

  Fly   456 NAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGT---GAAVGGGGPDDPFDAEWVANVAAAK 517
            .|:| .....:.......::....|:|....|:....   .|.||      |||       ||..
Human   425 KAQQ-QQQQQQQQQQQQQQQQQQAASVAPVPTMPPALQPFPAPVG------PFD-------AAPA 475

  Fly   518 QLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSF 552
            |::..||.|         |...||:  |..|...:
Human   476 QVAVFLPPP---------HMQPPFV--PAYPGLGY 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
numbNP_001260291.1 PTB_Numb 67..201 CDD:241298 100/133 (75%)
NumbF 269..374 CDD:283874 36/106 (34%)
NUMBLNP_004747.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68 15/28 (54%)
PTB_Numb 64..198 CDD:241298 100/133 (75%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 223..283 17/67 (25%)
NumbF 287..371 CDD:283874 36/106 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..421 14/86 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 434..464 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..609
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141148
Domainoid 1 1.000 191 1.000 Domainoid score I3250
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 320 1.000 Inparanoid score I2533
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1110016at2759
OrthoFinder 1 1.000 - - FOG0003748
OrthoInspector 1 1.000 - - otm41487
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11232
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2695
SonicParanoid 1 1.000 - - X2613
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1111.030

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