| Sequence 1: | NP_001260291.1 | Gene: | numb / 34263 | FlyBaseID: | FBgn0002973 | Length: | 556 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001005743.1 | Gene: | NUMB / 8650 | HGNCID: | 8060 | Length: | 651 | Species: | Homo sapiens |
| Alignment Length: | 591 | Identity: | 240/591 - (40%) |
|---|---|---|---|
| Similarity: | 299/591 - (50%) | Gaps: | 156/591 - (26%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 42 MDRLRRSFRDSFRRRKD-RVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEA 105
Fly 106 LKVLRQSR-----------RRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERG 159
Fly 160 FSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTR 224
Fly 225 TGSFRQQTLTE---------RLAMATVGTNERSVDG----PGSAMPGPPAAT---------VKPF 267
Fly 268 NPFAIERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQ 330
Fly 331 TPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNN 395
Fly 396 RSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSP----SRSEQSIETSTELPN 456
Fly 457 AEQWLGHVVRSTSP--AAPKRPTYLANVGRAQTLASGT------GAAVGG----GGPDDPFDAE- 508
Fly 509 WVANV----------AAAKQLSPDL-PIPSTARS-PLARHSTNPFIS-------------PPKAP 548
Fly 549 AQSFQV 554 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| numb | NP_001260291.1 | PTB_Numb | 67..201 | CDD:241298 | 97/144 (67%) |
| NumbF | 269..374 | CDD:283874 | 38/106 (36%) | ||
| NUMB | NP_001005743.1 | PTB_Numb | 23..168 | CDD:241298 | 97/144 (67%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 228..257 | 5/28 (18%) | |||
| NumbF | 258..338 | CDD:283874 | 38/106 (36%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 419..483 | 20/63 (32%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 623..651 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165141154 | |
| Domainoid | 1 | 1.000 | 191 | 1.000 | Domainoid score | I3250 |
| eggNOG | 0 | 0.000 | Not matched by this tool. | |||
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 320 | 1.000 | Inparanoid score | I2533 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 1 | 1.010 | - | - | D1110016at2759 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0003748 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41487 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_108078 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11232 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2695 |
| SonicParanoid | 1 | 1.000 | - | - | X2613 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 12 | 11.930 | |||||