DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and ldlrap1b

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001074104.1	Gene:	ldlrap1b / 791153	ZFINID:	ZDB-GENE-070112-1012	Length:	304	Species:	Danio rerio

Alignment Length:	240	Identity:	57/240 - (23%)
Similarity:	99/240 - (41%)	Gaps:	32/240 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSK-----------PHQWQADEEAVRSATCSFSVKYLGCVEVFE 95
            ||.|:.:.|...|.     |..:|           |..|....|.:..... |.:||||...|.|
Zfish     1 MDALKSAGRAIIRS-----PSLAKQSWISGKHKKLPENWTDTRETLLEGMV-FQLKYLGMTLVEE 59

  Fly    96 SRGMQVCEEALK----VLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNH 156
            .:|.::...|:|    ..:...::..:..|.||..|:.:.|..:..||.:.:|.::|:|..|:.|
Zfish    60 PKGEELSAAAVKRIVATAKAGGKKLQKVTLKVSPRGIILYDSASNQLIENVSIYRISYCTADKMH 124

  Fly   157 ERGFSYICRDGTTRRWMCHGFLACKDS-GERLSHAVGCAFAVCLE----RKQRRDKE--CGV--T 212
            ::.|:||.:........||.:|..|.. .:.::..|..||.|..|    .|:.::|:  ||.  .
Zfish   125 DKVFAYIAQSQRNETLECHAYLCTKRKVAQAVTLTVAQAFRVAFEFWQTAKEEKEKQVKCGSDGE 189

  Fly   213 MTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMP 257
            ....:::.:.....|.:.:..|..|.....|..:||  |..:|.|
Zfish   190 AASSSQSESSASLSSMKGEVATGDLLDLECGVKDRS--GKDAAHP 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	36/142 (25%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
ldlrap1b	NP_001074104.1	PTB_LDLRAP-mammal-like	43..165	CDD:269981	31/122 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840