DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and Fam43b

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001075141.1	Gene:	Fam43b / 625638	MGIID:	3651622	Length:	330	Species:	Mus musculus

Alignment Length:	218	Identity:	48/218 - (22%)
Similarity:	84/218 - (38%)	Gaps:	53/218 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEAL 106
            ::||.|.||.  ||:|..:.:...                :::|.|||......::|....::|:
Mouse    49 LERLGRVFRS--RRQKVELNKEDP----------------TYTVWYLGNAVTLHAKGDGCTDDAV 95

  Fly   107 KVLRQSRRRPVRGL---LHVSGDGLRVVDDE-TKGLIVDQ------TIEKVSFCAPDRNHERGFS 161
            ..: .:|..|..|.   |.:...|:|:...| :.|....:      .:.::::||.|..|.|.|:
Mouse    96 GRI-WARCGPGGGTKMKLTLGPHGIRMQPSERSSGASGGRRPAHAYLLPRITYCAADGRHPRVFT 159

  Fly   162 YICRDGTTRRWM---CHGFLACK----DSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKN 219
            ::.|.....:.:   ||..|..:    .|..||.|....|.....:|.||:.         |.::
Mouse   160 WVYRHQARHKAVVLRCHAVLLARAHKARSLARLLHQTALAAFSDFKRLQRQS---------DARH 215

  Fly   220 STFTRTGSFRQQTLTERLAMATV 242
                    .|||.|....|.|:|
Mouse   216 --------VRQQHLRAGGAAASV 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	29/150 (19%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
Fam43b	NP_001075141.1	PID_2	71..263	CDD:258856	40/178 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840