DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and nos1apa

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_021332861.1	Gene:	nos1apa / 553539	ZFINID:	ZDB-GENE-081024-1	Length:	505	Species:	Danio rerio

Alignment Length:	507	Identity:	111/507 - (21%)
Similarity:	189/507 - (37%)	Gaps:	121/507 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 DEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQS------RRRPVRGLLHVSGDGLRV 130
            :|||.:.. .:|..||:|.::|...........|::.:|..      :::.|.  :.||.||::|
Zfish    22 NEEAFQHG-INFEAKYIGSLDVARPNSRVEIVAAMRRIRYEFKVKNIKKKKVN--IIVSVDGVKV 83

  Fly   131 -----------VDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDS- 183
                       ..||:|.:::...|.::.:.:.|....:.||||.|||.:..:.|:.|.:.|.|
Zfish    84 ALRKKKKKKEWTWDESKMMVMQDPIYRIFYVSHDSQDLKIFSYIARDGQSNVFRCNVFKSKKKSQ 148

  Fly   184 GERLSHAVGCAFAVC----LERKQRR---------DKECGVTMTFDTKNSTFTRTG-SFRQQTLT 234
            ..|:...||.||.||    |:..|:.         ||.|             |.:| :.|:.|..
Zfish   149 AMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGDADKTC-------------TDSGVAGRELTGA 200

  Fly   235 ERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIE--------------RPHATPNMLERQ 285
            |:.|     .:|..:|.....:|.   :|:..|:....:              :|...|.:|...
Zfish   201 EKPA-----ADETDIDAEELPLPD---STMDEFSRGVTDLDAAKKDEDVSKDKKPSEEPVILLAS 257

  Fly   286 SSFRLSTIGSQSPFKRQMSL--RINDLPSNADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSA 348
            ....|.: ||..|....:|:  ::..|.....:|:          .||.:    .:|:|...|
Zfish   258 PKLLLPS-GSDLPSSTPLSVHHQLQLLQQQLTQQQ----------QQTQV----AVAQVHLLK-- 305

  Fly   349 GADPLSA-AAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHV 412
              |.||| ||...::.:::.|.|.|...||.....|:...::|..   :...|..:.::..:..:
Zfish   306 --DQLSAEAAARIEAQARVHQLLLQNKDLLQHISLLVKQIQELEL---KLAGQGSMGSQDSLLEI 365

  Fly   413 --HSYAPPTA--QVTPRVA-STTP-----TYQTLHSQSPSRSEQSI---ETSTELPNAEQWLGHV 464
              .:..||..  ..|||.. |..|     |..:|...||...:|.:   |....||...    |.
Zfish   366 TFRANVPPVLCDPSTPRPEDSILPPLNDGTQLSLPLCSPIGRDQGLIKFECFRFLPGPP----HQ 426

  Fly   465 VRSTSPAAPKRPTYLANVGRAQTLAS-------GTGAAVGGGGPDDPFDAEW 509
            ....||..|.:.  :::..|.:.|.|       .:|.|.......|..|..|
Zfish   427 QEEDSPDTPSQD--VSSSSRDELLGSLELLRFRESGIASEYESNTDESDESW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	40/150 (27%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874	24/121 (20%)
nos1apa	XP_021332861.1	PTB_CAPON-like	2..180	CDD:269968	41/160 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574054
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840