Protein Alignment numb and numbl

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_005173435.1
• Gene: numbl / 497616
• ZFINID: ZDB-GENE-051113-340
• Length: 640
• Species: Danio rerio
• Alignment Length: 654
• Identity: 239/654 - (36%)
• Similarity: 302/654 - (46%)
• Gaps: 214/654 - (32%)

  Fly    23 DVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKY 87
            :.::|.:..|     ...:|::||:|.|   |::...|||:|:||||||||||||...|:|.|:|
Zfish     9 ETEDGSTREF-----ESVEMNKLRQSLR---RKKPTYVPEASRPHQWQADEEAVRKGKCNFPVRY 65

  Fly    88 LGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAP 152
            ||.|||.|||||.|||||:|.|:.|.::.|:.:|.||.||||||||:||.|||||||||||||||
Zfish    66 LGLVEVDESRGMHVCEEAVKKLKVSGKKTVKAVLWVSADGLRVVDDKTKDLIVDQTIEKVSFCAP 130

  Fly   153 DRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDT 217
            |||:::.||||||||||||||||.|:|.||||||||||||||||.||||||||:||||||.:||.
Zfish   131 DRNYDKAFSYICRDGTTRRWMCHCFMALKDSGERLSHAVGCAFAACLERKQRREKECGVTASFDA 195

  Fly   218 KNSTFTRTGSFR-----QQTLTERLAMATVGTNERSVDG-----PGSAMP----GPPAATVKPFN 268
            ..::|.|.||||     ||:..|.: |..:...::.:.|     ||:|.|    |.|....:|..
Zfish   196 SRTSFVREGSFRVSSAAQQSDREDI-MKQIQDKKKEMCGISALPPGNASPPEGAGSPGERAEPGG 259

  Fly   269 PFAIERPHATPNMLERQSSFR----LSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPM 329
            |.||.|.||....|.||.|||    ||.  ..||||||:|||:|||||...|:..|.|.
Zfish   260 PHAIPRRHAPIEQLVRQGSFRGFPQLSQ--KNSPFKRQLSLRLNDLPSTLQRKTDFQTK------ 316

  Fly   330 QTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDL---N 391
                   :|:.|:.         |:.|. .|||::.||.:::...:         ...|||   .
Zfish   317 -------NPVPEMD---------LTVAG-EADSINALCSQINSSFT---------KPSEDLCAKT 355

  Fly   392 FNNNRSINQNIIAAEKQVQHVHSYAPPT--------------AQVTPRVASTTPTYQTLHSQSPS 442
            .||...|               |.|||.              .|:.|.|.|:.|..|..|.::||
Zfish   356 TNNCLPI---------------SCAPPAIPPPPAPPQATNLWVQIEPPVQSSPPIPQGGHKRTPS 405

  Fly   443 RSEQSIETSTELPNAEQWLGHVVRS------TSPAAPKRPT------------------------ 477
                         .||:||..|.::      |.|..|..||
Zfish   406 -------------EAERWLEEVAKAVKSQQQTPPTLPPPPTQQPPPVPTMPIAPGSLPTSMQPFP 457

  Fly   478 ---------------------------YLANVGRAQTL----------------------ASGTG 493
                                       |:..:..:.|.                      |:|||
Zfish   458 MAFDVTPAPVSMFTQQPLQPAFVPMQPYMPTLANSMTYPNASVPVVGITPSQMVANVFCSAAGTG 522

  Fly   494 AAVG---GGGPDDPFDAEWVANVAAAKQLS--PDLP--IPSTARSPLARHSTNPFISPPKA---P 548
            ..|.   |.||.        .......|.|  |.||  :|:|.           |.|||..   |
Zfish   523 GGVAIGVGMGPK--------TGTLGGSQHSAFPTLPGGLPTTT-----------FASPPTINGHP 568

  Fly   549 AQSF 552
            ..||
Zfish   569 QNSF 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	101/133 (76%)
		NumbF	269..374	CDD:283874	40/108 (37%)
numbl	XP_005173435.1	PTB_Numb	45..179	CDD:241298	101/133 (76%)
		NumbF	260..344	CDD:283874	40/108 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574044
Domainoid	1	1.000	197	1.000	Domainoid score	I3063
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	335	1.000	Inparanoid score	I2385
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110016at2759
OrthoFinder	1	1.000	-	-		FOG0003748
OrthoInspector	1	1.000	-	-		otm25571
orthoMCL	1	0.900	-	-		OOG6_108078
Panther	1	1.100	-	-	O	PTHR11232
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2613
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.900