Protein Alignment numb and dab2

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001314800.1
• Gene: dab2 / 404040
• ZFINID: ZDB-GENE-040303-1
• Length: 797
• Species: Danio rerio
• Alignment Length: 651
• Identity: 127/651 - (19%)
• Similarity: 213/651 - (32%)
• Gaps: 214/651 - (32%)

  Fly    50 RDSFRRRKDRVPESSKPH---QWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVL-- 109
            |.||.:.:.::||.:...   ::|.|  .||     :..|.:|..:|.::||.::|::::..|
Zfish    35 RTSFWKERRKIPEKTDEFLLARFQGD--GVR-----YKAKLIGVDDVQDARGDKMCQDSMMKLKG 92

  Fly   110 -----RQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYIC-RDGT 168
                 |...:...|..:::|..|:::||::|..:..:..:.|:||.|.|....|.|.|:| .:|.
Zfish    93 MAIAARSQGKHKQRIWINISLTGIKIVDEKTGVIEHEHVVNKISFIARDVTDNRAFGYVCGAEGQ 157

  Fly   169 TRRWMCHGFLACK--DSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQ 231
                  |.|.|.|  ...|.|...:...|.:....| ::::|.|     .......|..|..
Zfish   158 ------HQFFAIKTAQQAEPLVIDLKDLFQLIFNMK-KKEQEAG-----QKGEGNGTENGGD--- 207

  Fly   232 TLTERLAMATVGTNERSV------------------------------------------DGPGS 254
                  |:..|..||..|                                          |.|..
Zfish   208 ------ALLAVDGNENPVKSVEQMNLFGDMSTPPDIHSPTPDSVLLLELSDLFDGNQVNQDNPFI 266

  Fly   255 AMPGP-----------------PAATVKPF--NPFA----------------------IERPHAT 278
            ..|.|                 |..:..||  :||:                      :..|.::
Zfish   267 TNPSPLCNKPFDKSASSTSDLFPTLSSDPFSDDPFSPLNDQSDSVFSSNNESDFSSFLLNGPDSS 331

  Fly   279 PNMLERQSSFRL---STIGSQSPFKRQMSLRINDLPSNAD---RQRAFLTAAAGNP--------- 328
            .:...:...|..   |.:.::||..:...|.|:||....:   .|..||:.:..||
Zfish   332 EDPSPKSQQFNKLFDSQLSNESPNNQVQQLPISDLNGGTNSIFSQNPFLSISLNNPPIVNGLYSS 396

  Fly   329 ----MQTPLRSVS----PIAEVSPAKSAGADPLSAAAVAADSVSQLC---QELSQGLSLL-TQTD 381
                :|.||.:.|    .:.:.:|:.:.....|:|......::...|   :|.|.|..|. :...
Zfish   397 DPPVLQAPLCNGSNKQLALFQTNPSTTVQNGGLTALCPPPQNLKPRCARRREKSPGNDLFGSGLF 461

  Fly   382 ALLAAGEDLNFNNNRSINQNII--AAEKQVQHVHS----YAPPTAQVTPRVASTTPTYQTLHSQS 440
            |..|..|....|.|.||..::.  .....:....|    :||.||.|:             ..|:
Zfish   462 APPAQNESQASNQNASIPADLFNSTPSSTINAFGSMSLGHAPGTAPVS-------------WGQT 513

  Fly   441 PSRSEQSIETSTELP---------------NAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLAS 490
            |:...........:|               :|..| |.  :..||..|.          |.|.|.
Zfish   514 PTMFPPQAGVQVTIPGPPRPFPQPSAFGGLSAPAW-GQ--QGASPFGPP----------AGTQAW 565

  Fly   491 G-TGAAVGGG-----GPDDPFDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPA 549
            | .|||...|     ||        ||:.....|.:|  .:|..|...:.:.:..|...||:.|.
Zfish   566 GQPGAAAPVGTWPAPGP--------VASPFQPNQFAP--MMPPNAMMGMQQGAVAPPRPPPRPPV 620

  Fly   550 Q 550
            :
Zfish   621 K 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	35/146 (24%)
		NumbF	269..374	CDD:283874	26/152 (17%)
dab2	NP_001314800.1	PTB_Dab	47..196	CDD:269926	39/167 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574053
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930