DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and ldlrap1a

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_945331.1	Gene:	ldlrap1a / 368278	ZFINID:	ZDB-GENE-030328-13	Length:	287	Species:	Danio rerio

Alignment Length:	232	Identity:	55/232 - (23%)
Similarity:	101/232 - (43%)	Gaps:	28/232 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSK-----------PHQWQADEEAVRSATCSFSVKYLGCVEVFE 95
            ||.|:     |.||...|.|..:|           |..|....|.:... .:|::::||...|.:
Zfish     1 MDVLK-----SARRAFIRSPSLTKQSWSSGKHKKLPENWTDTRETLLEG-MTFNLRHLGMTLVDQ 59

  Fly    96 SRGMQVCEEALK----VLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNH 156
            .:|.::...|:|    ..:.|.::..:..|.||..|:.:.|..:..||.:.:|.::|:|..|:.|
Zfish    60 PKGEELSAAAVKRIVATAKASGKKLPKVALKVSPQGIILYDSVSNQLIENISIYRISYCTADKTH 124

  Fly   157 ERGFSYICRDGTTRRWMCHGFLACKDS-GERLSHAVGCAFAVCLE-RKQRRDKECGVTMTFDTKN 219
            ::.|::|.::.......||.||..|.. .:.::..|..||.|..| .:..:|::     .:|:..
Zfish   125 DKVFAFIAQNQQNETLECHAFLCAKRKVAKAVTLTVAQAFRVAFEFWEVAKDEK-----KWDSAG 184

  Fly   220 STFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAM 256
            .|...:.|.|..:||.....|....|...::...||:
Zfish   185 ETSNSSQSDRSVSLTSLKVGAAATENLLEIEDYTSAL 221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	34/139 (24%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
ldlrap1a	NP_945331.1	PTB_LDLRAP-mammal-like	43..165	CDD:269981	29/122 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574059
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840