DRSC/TRiP Functional Genomics Resources

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Protein Alignment numb and Mapk8ip2

DIOPT Version :9

Sequence 1:NP_001260291.1 Gene:numb / 34263 FlyBaseID:FBgn0002973 Length:556 Species:Drosophila melanogaster
Sequence 2:NP_001094190.1 Gene:Mapk8ip2 / 315220 RGDID:1309727 Length:835 Species:Rattus norvegicus


Alignment Length:381 Identity:72/381 - (18%)
Similarity:123/381 - (32%) Gaps:126/381 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   246 ERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDL 310
            |...||.|....|..:.:.:......|..|....:...|.::..|:|:|:|.......:......
  Rat   100 EEEEDGDGDGRAGGGSGSQELSGESLIPSPSIEESHKLRPTTLHLTTLGAQDSLNNNSNGGFTSA 164

  Fly   311 PSNADRQRAFLTAAAGNPMQTPLRSV-SPIA-------EV----------------SPAKSAGAD 351
            |.::.::     ....:|:|.||:.: :|:.       ||                .|..|.||.
  Rat   165 PPSSWQE-----TVLRSPVQEPLKELPAPLLPAEEEHHEVQSLARPGCDCEGNQPPEPPASGGAS 224

  Fly   352 PLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYA 416
            |.|...:.||    |....|.|......:..|.:.|.|                        |..
  Rat   225 PSSDPGIEAD----LRSHSSGGHEGRRSSQELSSPGSD------------------------SEE 261

  Fly   417 PPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAA--------- 472
            ...|::...::|.:.|...|.|.|.|.|.:    |:.|.|:      :..::|||:         
  Rat   262 AGGARLGRMISSISETELELSSDSGSSSGR----SSHLTNS------IEEASSPASEPEPEPEPE 316

  Fly   473 -----PKRPTYLANVGRAQTLASGTGAAVGGGGPDDP-----FDAEWVANVAAAKQ--------- 518
                 |:||.:|. ||:     ..|.:....|...:|     .|:.|:.:...::.         
  Rat   317 PLHEPPRRPAFLP-VGQ-----DDTNSEYESGSESEPDLSEDADSPWLLSNLVSRMISEGSSPIR 375

  Fly   519 -----LSPDLPIP----STARSPLARHSTNPFI----------------SPPKAPA 549
                 |||..|.|    ::..:|:.:...:|..                .||.|||
  Rat   376 CPGQCLSPPAPRPPEEAASQANPVPQDCPDPEAVAGPHVELVDMDTLCGPPPPAPA 431

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
numbNP_001260291.1 PTB_Numb 67..201 CDD:241298
NumbF 269..374 CDD:283874 25/128 (20%)
Mapk8ip2NP_001094190.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 44..357 59/305 (19%)
JNK-binding domain (JBD). /evidence=ECO:0000250|UniProtKB:Q9ERE9 111..278 33/199 (17%)
Necessary for interaction with FGF13. /evidence=ECO:0000250|UniProtKB:Q13387 242..509 42/230 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 369..509 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 544..579
SH3_JIP2 619..673 CDD:212875
PTB_JIP 690..835 CDD:269923
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166334818
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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