DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment numb and Numbl

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_006228627.1	Gene:	Numbl / 292732	RGDID:	1307579	Length:	641	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	232/621 - (37%)
Similarity:	296/621 - (47%)	Gaps:	152/621 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 NGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGC 90
            :|...:||........|::||:|.|   ||:...|||:|:||||||||:|||..||||.|:|||.
  Rat    53 SGPPETFRTESDGAGTMNKLRQSLR---RRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGH 114

  Fly    91 VEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRN 155
            |||.|||||.|||:|:|.|:...|:.|:.:|.||.||||||||:||.|:||||||||||||||||
  Rat   115 VEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRN 179

  Fly   156 HERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNS 220
            .::.|||||||||||||:||.|||.||||||||||||||||.||||||||:||||||..||...:
  Rat   180 LDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRT 244

  Fly   221 TFTRTGSFRQQTLTERLAMATVGTNERS------VDGPGSAMPG---PPAATVKP---------- 266
            :|.|.||||... ..|.|....|..:::      ...||.|.||   |..||..|
  Rat   245 SFAREGSFRLSG-GGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPV 308

  Fly   267 ---FNPFAIERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAG 326
               ....||.|.||....|.||.|||.....||  ||||||:|||:|:|||...|
  Rat   309 AAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQR---------- 363

  Fly   327 NPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLN 391
               :|..:....:.|:.|..:..:|.:||          ||.::|...:         :||..:.
  Rat   364 ---RTDFQVKGTVPEMEPPGTGDSDGISA----------LCTQISSSFA---------SAGAPVP 406

  Fly   392 FNNNRSINQNIIAAEKQVQHVHSYAPPTAQV------TPRVASTTPTYQTLHSQSPSRSEQSIET 450
                                    .||:|..      .|.|.:.| .:|..|.::||.:|:.:|.
  Rat   407 ------------------------GPPSATTGTSAWGEPSVPAAT-AFQPGHKRTPSEAERWLEE 446

  Fly   451 STELPNA------------------EQWLGHVVRSTSPAAPKRPT---YLANVGRAQTLASGTG- 493
            .:::..|                  :|.......|..|.....||   :...||...|.|:...
  Rat   447 VSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAV 511

  Fly   494 -------------AAVGGGGPDDP-------FDAEWVANV-AAAKQLSPD----------LPIPS 527
                         |..|.|.|..|       ..::.|||. .:|.||.|.          .|.|:
  Rat   512 FLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPT 576

  Fly   528 TARSP--LARHSTNPFISPPK-APAQS-----FQVQ 555
            ...:|  .||...|....||: |||.:     |:.|
  Rat   577 APSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQ 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	100/133 (75%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874	36/106 (34%)
Numbl	XP_006228627.1	PTB_Numb	91..225	CDD:241298	100/133 (75%)
Numbl	XP_006228627.1	NumbF	314..398	CDD:283874	36/106 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334814
Domainoid	1	1.000	191	1.000	Domainoid score	I3143
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	324	1.000	Inparanoid score	I2407
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110016at2759
OrthoFinder	1	1.000	-	-		FOG0003748
OrthoInspector	1	1.000	-	-		otm45604
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11232
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2613
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.000