Protein Alignment numb and Dab1

DIOPT Version :10

• Sequence 1: NP_523523.2
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_017448664.1
• Gene: Dab1 / 266729
• RGDID: 628770
• Length: 588
• Species: Rattus norvegicus
• Alignment Length: 623
• Identity: 129/623 - (20%)
• Similarity: 224/623 - (35%)
• Gaps: 164/623 - (26%)

  Fly    36 KKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQ 100
            |.|.||         ||.::.:|| .|::...:::.  |.||     :..|.:|..||..:||.:
  Rat    12 KTSAKK---------DSRKKGQDR-SEATLIKRFKG--EGVR-----YKAKLIGIDEVSAARGDK 59

  Fly   101 VCEEALKVL-------RQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHER 158
            :|::::..|       |.......:..|.:|..|:::.|::|..|.....:.::|:.|.|....|
  Rat    60 LCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHR 124

  Fly   159 GFSYIC-RDGTTRRWMCHGFLACK--DSGERLSHAVGCAFAVCLERKQR--------RDKEC--G 210
            .|.|:| ::|.      |.|:|.|  .:.|.:...:...|.:..|.|||        :||:|  .
  Rat   125 AFGYVCGKEGN------HRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQA 183

  Fly   211 VTMTF---DTKNSTFT----RTG--SFRQQTLTERLAMATVGTNERSV-DGPGSAMPGPPAATVK 265
            |..|.   |.::..:.    ..|  ..|.....|.:........:..| |.|.|    .|.:..:
  Rat   184 VYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKS----QPVSNSQ 244

  Fly   266 PFNPFAIERPHATPN---------MLERQSSF-RLSTIGSQS-------------PFKRQMSLRI 307
            |...|......||||         :||...:. :|...|..|             |....:....
  Rat   245 PLEDFEARFAAATPNGNLSMDFDELLEATKAVTQLELFGDMSTPPDITSPPTPATPGDAFLPAPS 309

  Fly   308 NDLPSNAD--RQRAFLTAAAGN----------------PM---QTPLRSVSPIAEVSPAKSAGAD 351
            ..||.:||  ...:|.|||..:                |:   |..:.:..|:|:|.|    ||.
  Rat   310 QTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIP----GAQ 370

  Fly   352 PLS-----------------------AAAVAADSVSQLCQELSQG----LSLLTQTDALLAAGED 389
            |::                       ||.:...:|..|...:.||    |:.:..|:
  Rat   371 PIAWGQPGLFPATQQPWPTVAGQFPPAAFMPTQTVMPLPAAMFQGPLTPLATVPGTN-------- 427

  Fly   390 LNFNNNRSINQNIIAAEKQVQHVH-----SYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIE 449
               ::.||..|:....:|..:.:.     :..||.....|...|.|.|     |::.|.....:.
  Rat   428 ---DSARSSPQSDKPRQKMGKEMFKDFQMAQPPPVPSRKPDQPSLTCT-----SEAFSSYFNKVG 484

  Fly   450 TSTELPNAEQW-LGHV----VRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEW 509
            .:.:..:.:.: :..:    |.||:|:....||   ...|..:.:..:.:.|.....||.|:..:
  Rat   485 VAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPT---PAPRQSSPSKSSASHVSDPTADDIFEEGF 546

  Fly   510 VANVAAAKQLSPDLPIPSTARSPLARHSTNPF---ISP 544
            .:...:.:|.:||....|:...|....|..|.   |||
  Rat   547 ESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISP 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_523523.2	PTB_Numb	67..201	CDD:241298	32/143 (22%)
		NumbF	269..374	CDD:461874	34/175 (19%)
Dab1	XP_017448664.1	PTB_Dab	25..174	CDD:269926	39/162 (24%)
		PHA03247	<287..580	CDD:223021	56/315 (18%)