DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and LDLRAP1

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_056442.2	Gene:	LDLRAP1 / 26119	HGNCID:	18640	Length:	308	Species:	Homo sapiens

Alignment Length:	235	Identity:	59/235 - (25%)
Similarity:	100/235 - (42%)	Gaps:	31/235 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALK--- 107
            ::|:....|.||       .|..|....|.:..... ||:||||...|.:.:|.::...|:|
Human    19 KQSWGGGGRHRK-------LPENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIV 75

  Fly   108 -VLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRR 171
             ..:.|.::..:..|.||..|:.:.|:.|..||.:.:|.::|:|..|:.|::.|:||.:....:.
Human    76 ATAKASGKKLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQS 140

  Fly   172 WMCHGFLACK-DSGERLSHAVGCAFAVCL-------ERKQRRDKE-------CGVTMTFDTKNST 221
            ..||.||..| ...:.::..|..||.|..       |.|::|||.       .|..........:
Human   141 LECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKEKRDKASQEGGDVLGARQDCTPSLKS 205

  Fly   222 FTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPA 261
            ...||:......|.:..::||..|..::|    .:|.|.|
Human   206 LVATGNLLDLEETAKAPLSTVSANTTNMD----EVPRPQA 241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	38/145 (26%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
LDLRAP1	NP_056442.2	PTB_LDLRAP-mammal-like	44..166	CDD:269981	34/122 (28%)
		Clathrin box. /evidence=ECO:0000269\|PubMed:12221107	212..216		0/3 (0%)
		AP-2 complex binding. /evidence=ECO:0000269\|PubMed:12221107	249..276
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000269\|PubMed:16516836	257..266
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141159
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840