Protein Alignment numb and Fam43a

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_808300.1
• Gene: Fam43a / 224093
• MGIID: 2676309
• Length: 424
• Species: Mus musculus
• Alignment Length: 509
• Identity: 102/509 - (20%)
• Similarity: 165/509 - (32%)
• Gaps: 180/509 - (35%)

  Fly    27 GKSASFRFSKKS------PK-KMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFS 84
            |.:.|..:|..|      |: .:.|:...||.   :||       |.|        :.|...:::
Mouse    25 GYAVSLHYSALSSLARACPEGALSRVGSMFRS---KRK-------KLH--------ITSEDPTYT 71

  Fly    85 VKYLGCVEVFESRGMQVCEEAL-KVLRQSR--RRPVRGLLHVSGDGLRVVDDETKGLIVD---QT 143
            |.|||.....::||....:.|: |:..:|.  |:..:..|.||..|:|:|..|.:.|...   ..
Mouse    72 VLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYL 136

  Fly   144 IEKVSFCAPDRNHERGFSYICRDGTTRRWM---CHGFLACKDSGERLSHAVGCAFAVCL------ 199
            :.:|::|..|....:.|:::.|.....:.:   ||..|..|....:       |.|:.|
Mouse   137 LHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQ-------AMALLLYQTSAN 194

  Fly   200 -----ERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGP 259
                 :|.:|||         |.::         :||.|.....:..|...:..:.||
Mouse   195 ALAEFKRLKRRD---------DARH---------QQQELVGAHTIPLVPLRKLLLHGP------- 234

  Fly   260 PAATVKPFNPFAIERPHATPNM---------------LERQSSFRLST----------IGSQSPF 299
              ...||    .:||..:.|.:               |:.:....|..          :|...|.
Mouse   235 --CCYKP----PVERSRSAPKLGSITEDLLGEQQEEELQEEEEEHLEDCLEEEEEEDGVGDGDPA 293

  Fly   300 KRQMSLRINDLPSNADRQRAFLTAA------AGNPMQTPLRSVSPIAEVSPAKSAGAD-PLSAAA 357
            :.:           |:.|||.:.|.      ..:|::...........||...|:|.. |||..
Mouse   294 EEE-----------AEAQRALVVAMQLECEDLLDPLENGHEEALGDGGVSLGPSSGTSLPLSVC- 346

  Fly   358 VAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQV 422
             |:|..:||.|              |::...||:|.|:.|                     |.:.
Mouse   347 -ASDMKAQLSQ--------------LISDLGDLSFGNDVS---------------------TLET 375

  Fly   423 TPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRP 476
            ..||.       .|.|...:.||.|||..          |......||..|..|
Mouse   376 DLRVT-------RLLSGESTGSESSIEGG----------GLDATPVSPGNPSGP 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	32/153 (21%)
		NumbF	269..374	CDD:283874	25/136 (18%)
Fam43a	NP_808300.1	PID_2	69..256	CDD:258856	46/224 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	261..299		5/48 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..424		12/41 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840