DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment numb and Numbl

DIOPT Version :9

Sequence 1:NP_001260291.1 Gene:numb / 34263 FlyBaseID:FBgn0002973 Length:556 Species:Drosophila melanogaster
Sequence 2:XP_006539678.1 Gene:Numbl / 18223 MGIID:894702 Length:608 Species:Mus musculus


Alignment Length:611 Identity:231/611 - (37%)
Similarity:295/611 - (48%) Gaps:142/611 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 NGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGC 90
            :|...:||........|::||:|.|   ||:...|||:|:||||||||:|||..||||.|:|||.
Mouse    30 SGPPETFRTESDGAGTMNKLRQSLR---RRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGH 91

  Fly    91 VEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRN 155
            |||.|||||.|||:|:|.|:...|:.|:.:|.||.||||||||:||.|:||||||||||||||||
Mouse    92 VEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRN 156

  Fly   156 HERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNS 220
            .::.|||||||||||||:||.|||.||||||||||||||||.||||||||:||||||..||...:
Mouse   157 LDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRT 221

  Fly   221 TFTRTGSFRQQTLTERLAMATVGTNERS------VDGPGSAMPG---PPAATVKP---------- 266
            :|.|.||||... ..|.|....|..:::      ...||.|.||   |..||..|          
Mouse   222 SFAREGSFRLSG-GGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPV 285

  Fly   267 ---FNPFAIERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAG 326
               ....||.|.||....|.||.|||.....||  ||||||:|||:|:|||...|          
Mouse   286 AAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQR---------- 340

  Fly   327 NPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLN 391
               :|..:....:.|:.|..:..:|.::|          ||.::|...:         :||...:
Mouse   341 ---RTDFQVKGTVPEMEPPGTGDSDGINA----------LCTQISSSFA---------SAGAPAS 383

  Fly   392 FNNNRSINQNIIAAEKQVQHVHSYAPPTAQV------TPRVASTTPTYQTLHSQSPSRSEQSIET 450
                                    .||.|..      .|.|.:.. .:|..|.::||.:|:.:|.
Mouse   384 ------------------------GPPPATTGTSAWGEPSVPAAA-AFQPGHKRTPSEAERWLEE 423

  Fly   451 STELPNA--------EQWLGHVVRSTSPAAPKRPT---YLANVGRAQTLASGTG----------- 493
            .:::..|        :|.......|..|.....||   :.|.||...|.|:...           
Mouse   424 VSQVAKAQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSAPVGPFDTAAAQVAVFLPPTHMQPP 488

  Fly   494 ---AAVGGGGPDDP-------FDAEWVANV-AAAKQLSPD----------LPIPSTARSP--LAR 535
               |..|.|.|..|       ..::.|||. .:|.||.|.          .|.|:...:|  .||
Mouse   489 FVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPAAPSAPGGQAR 553

  Fly   536 HSTNPFISPPK-APAQS-----FQVQ 555
            ...|....||: |||.:     |:.|
Mouse   554 PRPNGAPWPPEPAPAPAPELDPFEAQ 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
numbNP_001260291.1 PTB_Numb 67..201 CDD:241298 100/133 (75%)
NumbF 269..374 CDD:283874 35/106 (33%)
NumblXP_006539678.1 PTB_Numb 68..202 CDD:241298 100/133 (75%)
PHA03247 <263..594 CDD:223021 90/374 (24%)
NumbF 293..375 CDD:368837 35/104 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167831096
Domainoid 1 1.000 191 1.000 Domainoid score I3237
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 320 1.000 Inparanoid score I2510
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003748
OrthoInspector 1 1.000 - - otm43537
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11232
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2695
SonicParanoid 1 1.000 - - X2613
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.020

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