Protein Alignment numb and num-1

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_001129904.1
• Gene: num-1 / 180367
• WormBaseID: WBGene00003830
• Length: 682
• Species: Caenorhabditis elegans
• Alignment Length: 609
• Identity: 205/609 - (33%)
• Similarity: 278/609 - (45%)
• Gaps: 149/609 - (24%)

  Fly    24 VKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDR---------VPESSKPHQWQADEEAVRSA 79
            :.|.||:.|      .|.|||||||.|.. ::|:||         |...||..|||.||.|||:.
 Worm   136 IPNDKSSIF------SKGMDRLRRSLRLP-KKRRDRSHDRHLSPDVTGGSKTEQWQPDEGAVRTG 193

  Fly    80 TCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDD-ETKGLIVDQT 143
            ||.|:|||||.|||:|||||||||.|||.|:.|||:||:.:|:||||||||||. .::||:||||
 Worm   194 TCCFNVKYLGSVEVYESRGMQVCEGALKSLKASRRKPVKAVLYVSGDGLRVVDQGNSRGLLVDQT 258

  Fly   144 IEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKE 208
            |||||||||||..::||:||||||.:||||||||||.|::||||||||||||::|||:|:|||:|
 Worm   259 IEKVSFCAPDRQTDKGFAYICRDGASRRWMCHGFLATKETGERLSHAVGCAFSICLEKKKRRDEE 323

  Fly   209 CGVTMTFDTKNSTF---------------TRTGSFRQQTLTERLAMA------TVGTNERSVDGP 252
            .........:.||.               |..|:..|.....|..:|      .|...:|.:|..
 Worm   324 TAQVNVQSAQESTSSTPPKDIFHPNWEDNTSEGTSTQNPSNSRSNLAYQSFRKHVSIEDRYLDPQ 388

  Fly   253 GSAMPGPPAAT-VKPFNPFAIERPHATPNMLERQSSFRL--STIGSQSPFKRQMSLRI--NDLPS 312
            ...:...||:. :......:..||...|.:..||.|.|.  ....|...|||.||||.  |:...
 Worm   389 SVIINEVPASNHMDEIRRISKPRPTGNPALFLRQGSLRAPPDMPSSSDQFKRNMSLRTVSNNPTE 453

  Fly   313 NADRQRAFLTAAAGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSL- 376
            .:..:::|.|.....|:.                ....|||                   ||.:
 Worm   454 RSPEKKSFGTQLYNEPIY----------------EGDEDPL-------------------GLGIT 483

  Fly   377 ---LTQTDALLA----AGEDLNFNN---------NRSINQNIIAAEKQVQHVHSYAPPTAQVTPR 425
               :|:|...|:    .|.:||:.:         ..:.|.:.:||..|    ::...||.....:
 Worm   484 PPVVTKTSGSLSNNGLDGINLNWKSIPAPVHQMQQHNANGDFVAAWPQ----NTIEKPTVGPLDK 544

  Fly   426 VASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLAS 490
            :..   .::.:...|.|..|   .|.|....|::||..|:|.:...:|..|:       :...::
 Worm   545 LQK---QFEDIKLISISSGE---NTPTTRSKADEWLDDVLRVSMSMSPTSPS-------SDPPST 596

  Fly   491 GTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLPI-------------------PSTARSPLA-- 534
            .:.:.:...|| .|..|            .|.||:                   .||..||..
 Worm   597 SSYSVLPKSGP-PPAHA------------PPPLPVRQAVSNGSPSIYQQQLQQANSTRNSPAGIN 648

  Fly   535 -RHSTNPF-IS-PPKAPAQSFQVQ 555
             ..|.||. || ||..|...|.||
 Worm   649 WNSSPNPMKISQPPAKPVDPFDVQ 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	98/134 (73%)
		NumbF	269..374	CDD:283874	22/108 (20%)
num-1	NP_001129904.1	PTB_Numb	181..316	CDD:241298	98/134 (73%)
		NumbF	410..>445	CDD:368837	13/34 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157403
Domainoid	1	1.000	197	1.000	Domainoid score	I1819
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	250	1.000	Inparanoid score	I2006
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110016at2759
OrthoFinder	1	1.000	-	-		FOG0003748
OrthoInspector	1	1.000	-	-		oto19489
orthoMCL	1	0.900	-	-		OOG6_108078
Panther	1	1.100	-	-	LDO	PTHR11232
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2695
SonicParanoid	1	1.000	-	-		X2613
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.930