Protein Alignment numb and FAM43B

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_997217.1
• Gene: FAM43B / 163933
• HGNCID: 31791
• Length: 329
• Species: Homo sapiens
• Alignment Length: 297
• Identity: 53/297 - (17%)
• Similarity: 86/297 - (28%)
• Gaps: 127/297 - (42%)

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRG-------- 98
            ::||.|.||.  ||:|..:.:...                :::|.|||......::|
Human    49 LERLGRVFRS--RRQKVELNKEDP----------------TYTVWYLGNAVTLHAKGDGCTDDAV 95

  Fly    99 -------------------------MQVCEEALKVLRQSRRRPVRGLLHVSGDGLRVVDDETKGL 138
                                     ||.||.: .......|||....|
Human    96 GKIWARCGPGGGTKMKLTLGPHGIRMQPCERS-AAGGSGGRRPAHAYL----------------- 142

  Fly   139 IVDQTIEKVSFCAPDRNHERGFSYICRDGTTRRWM---CHGFLACKDSGER-----LSHAVGCAF 195
                 :.::::|..|..|.|.|:::.|.....:.:   ||..|..:....|     |......||
Human   143 -----LPRITYCTADGRHPRVFAWVYRHQARHKAVVLRCHAVLLARAHKARALARLLRQTALAAF 202

  Fly   196 AVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPP 260
            : ..:|.||:.         |.::        .|||.|              ...|..:::|..|
Human   203 S-DFKRLQRQS---------DARH--------VRQQHL--------------RAGGAAASVPRAP 235

  Fly   261 AATVK----PFNPFAIERPHATPNMLERQSSFRLSTI 293
            ...:.    .:.|...||....|         |||:|
Human   236 LRRLLNAKCAYRPPPSERSRGAP---------RLSSI 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	26/174 (15%)
		NumbF	269..374	CDD:283874	8/25 (32%)
FAM43B	NP_997217.1	PH-like	71..263	CDD:418428	44/255 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		8/28 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840