Protein Alignment numb and FAM43A

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: NP_710157.2
• Gene: FAM43A / 131583
• HGNCID: 26888
• Length: 423
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 103/504 - (20%)
• Similarity: 172/504 - (34%)
• Gaps: 157/504 - (31%)

  Fly    27 GKSASFRFSKKS------PK-KMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFS 84
            |.:.|..:|..|      |: .:.|:...||.   :||       |.|        :.|...:::
Human    25 GYAVSLHYSALSSLARACPEGALSRVGSMFRS---KRK-------KLH--------ITSEDPTYT 71

  Fly    85 VKYLGCVEVFESRGMQVCEEAL-KVLRQSR--RRPVRGLLHVSGDGLRVVDDETKGLIVD---QT 143
            |.|||.....::||....:.|: |:..:|.  |:..:..|.||..|:|:|..|.:.|...   ..
Human    72 VLYLGNATTIQARGDGCTDLAVGKIWSKSEAGRQGTKMKLTVSAQGIRMVHAEERALRRPGHLYL 136

  Fly   144 IEKVSFCAPDRNHERGFSYICRDGTTRRWM---CHGFLACKDSGERLSHAVGCAFAVCL------ 199
            :.:|::|..|....:.|:::.|.....:.:   ||..|..|....:       |.|:.|
Human   137 LHRVTYCVADARLPKVFAWVYRHELKHKAVMLRCHAVLVSKPEKAQ-------AMALLLYQTSAN 194

  Fly   200 -----ERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGP 259
                 :|.:|||         |.::         :||.|.....:..|...:..:.||
Human   195 ALAEFKRLKRRD---------DARH---------QQQELVGAHTIPLVPLRKLLLHGP------- 234

  Fly   260 PAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAA 324
              ...||    .:||..:.|.:    .|.....:|.|..         .:|....:.::
Human   235 --CCYKP----PVERSRSAPKL----GSITEDLLGEQLE---------QELQEEEEEEQ------ 274

  Fly   325 AGNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAAD-SVSQLCQELSQGLSLLTQTDALLAAGE 388
               |...|....:..||..||:.. |:...|..||.. ....|...|..|     :.:||...|.
Human   275 ---PEGCPEEEENRAAEGDPAEEE-AEAQRALVVAMHFECGDLLDTLENG-----RGEALGGGGG 330

  Fly   389 DLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTE 453
            .|.                          |.|...|.:         |.|.|..::|.| :..::
Human   331 SLG--------------------------PGAGPPPLL---------LGSASDMKAELS-QLISD 359

  Fly   454 LPNAEQWLGHVVRSTSPAAPKRPTYLANVGRAQTLASGTGAAVGGGGPD 502
            |  .|...|:.||:..  |..|.|.|.:..     ::|:.:::.|||||
Human   360 L--GELSFGNDVRTLQ--ADLRVTRLLSGD-----STGSESSIEGGGPD 399

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	32/153 (21%)
		NumbF	269..374	CDD:283874	19/105 (18%)
FAM43A	NP_710157.2	PID_2	69..256	CDD:317162	47/228 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..298		8/53 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	321..344		7/57 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	382..423		6/23 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141160
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840