DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment numb and Dab2

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_075607.2	Gene:	Dab2 / 13132	MGIID:	109175	Length:	766	Species:	Mus musculus

Alignment Length:	675	Identity:	137/675 - (20%)
Similarity:	226/675 - (33%)	Gaps:	210/675 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LERGFTRGKFGDVKNGKSASFRFSKKSPKKMDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAV 76
            :|...|.|:.......|:.|.:..||..:|.|....:     |.:.|.|
Mouse     5 VETSTTNGQPDQQAAPKAPSKKEKKKGSEKTDEYLLA-----RFKGDGV---------------- 48

  Fly    77 RSATCSFSVKYLGCVEVFESRGMQVCEEALKVL-------RQSRRRPVRGLLHVSGDGLRVVDDE 134
                 .:..|.:|..:|.::||.::.::::..|       |...:...|..:::|..|::::|::
Mouse    49 -----KYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEK 108

  Fly   135 TKGLIVDQTIEKVSFCAPDRNHERGFSYIC-RDGTTRRWMCHGFLACK--DSGERLSHAVGCAFA 196
            |..:..:..:.|:||.|.|....|.|.|:| .:|.      |.|.|.|  ...|.|...:...|.
Mouse   109 TGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQ------HQFFAIKTGQQAEPLVVDLKDLFQ 167

  Fly   197 VCLE-RKQRRDK----------ECG--VTMTFDTKNS-------------TFTRTGSFRQQTLTE 235
            |... :|:..||          |.|  ..||.|.:.:             ..:........|.::
Mouse   168 VIYNVKKKEEDKKKVEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNSPTESK 232

  Fly   236 RLAM----ATVGTNERSV-DGP-------GSAMPGP-PAATVKPFNPFAI--------------E 273
            .:.:    :.:.||:.|: :.|       ..::|.| |.|:..|.|.|:.              :
Mouse   233 DILLVDLNSEIDTNQNSLRENPFLTNGVTSCSLPRPKPQASFLPENAFSANLNFFPTPNPDPFRD 297

  Fly   274 RPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPS-----NAD-----------RQRAFLT 322
            .|.|.|:. ...|||...|    ||.:::.||..:..|.     |.|           ..|....
Mouse   298 DPFAQPDQ-SAPSSFDSLT----SPDQKKASLSSSSTPQSKGPLNGDTDYFGQQFDQLSNRTGKP 357

  Fly   323 AAAGNPMQTP-------LRSVSPIAE---------VSPAKSAGADP--------------LSAAA 357
            .|.|.|...|       :|:.:.::|         .||....|:.|              .|..:
Mouse   358 EAQGGPWPYPSSQTQQAVRTQNGVSEREQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLESSVQS 422

  Fly   358 VAADSVSQL--CQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTA 420
            .|.||::.:  .|....|....|..    ::..||       :..:|.|:|           |..
Mouse   423 SAHDSIAIIPPPQSTKPGRGRRTAK----SSANDL-------LASDIFASE-----------PPG 465

  Fly   421 QVTPRVASTTPTYQTL---HSQSPSRSEQSIETST---ELPNAEQWLGHVVRSTSPAAP------ 473
            |::|......|....|   ...:|:.....:...|   ..|.|..|...|...::...|
Mouse   466 QMSPTGQPAVPQSNFLDLFKGNAPAPVGPLVGLGTVPVTPPQAGPWTPVVYSPSTTVVPGAIISG 530

  Fly   474 KRPTYLANVGRAQTLASGTGAAVGGGGPDDPFDAEWVANVAAAKQLSPDLP---IPSTARSPLAR 535
            :.|::      .|.|..||..||          ..|..:.:.|...||..|   .|:|:.:|.|.
Mouse   531 QPPSF------GQPLVFGTTPAV----------QVWNQSPSFATPASPPPPTVWCPTTSVAPNAW 579

  Fly   536 HST----NPFIS-----PPKAPAQS 551
            .||    |||.|     ||....||
Mouse   580 SSTSPLGNPFQSNNIFPPPTMSTQS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	30/144 (21%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874	31/166 (19%)
Dab2	NP_075607.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		8/30 (27%)
		PTB_Dab	35..171	CDD:269926	34/167 (20%)
		Required for localization to clathrin-coated pits	230..447		43/221 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	284..482		41/224 (18%)
		PHA03247	<288..608	CDD:223021	75/360 (21%)
		DPF 1	293..295		0/1 (0%)
		DPF 2	298..300		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..630		4/9 (44%)
		Sufficient for interaction with GRB2. /evidence=ECO:0000269\|PubMed:9569023	600..730		2/5 (40%)
		Required for interaction with CSK. /evidence=ECO:0000250	617..625
		Required for interaction with MYO6. /evidence=ECO:0000269\|PubMed:11906161	647..766
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	659..683
		Required for interaction with GRB2 and CSK. /evidence=ECO:0000250	661..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..766
		Sufficient for interaction with SH3KBP1 SH3 domain	707..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831103
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930