DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and mapk8ip1

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	XP_031756343.1	Gene:	mapk8ip1 / 100496373	XenbaseID:	XB-GENE-478437	Length:	680	Species:	Xenopus tropicalis

Alignment Length:	226	Identity:	50/226 - (22%)
Similarity:	91/226 - (40%)	Gaps:	61/226 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GKFGDVKNGKS------ASFRFSKKSPKKMD---------------------RLRRSFRDSF--- 53
            |.|..:.||:.      |.|||..:.|.:::                     .:|...|..|
Frog   447 GLFSCLINGEEREQTHRAVFRFMPRHPDELELEVEDPLLVEVQAEDYWYEAYNMRTGERGIFPAY 511

  Fly    54 -----RRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEALKVLRQSR 113
                 .:..|.:.||..|: | .|:         |.:|:||.|:|...:|..|...|::.:..||
Frog   512 YAVQVTKEPDPIAESRAPN-W-VDQ---------FWLKFLGSVQVPYHKGTDVLCTAMQKIAVSR 565

  Fly   114 R------RPVRGLLHVSGDGLRVVDDETKGLIVDQT--------IEKVSFCAPDRNHERGFSYIC 164
            |      .|...:|.:|..|:::.......|...|.        ::.:|||:....:.:.|.:|.
Frog   566 RLTVLSNPPANCILEISMRGVKIAVQGEDPLDHSQVNTCSHFFQLKNISFCSYHPKNSKYFGFIT 630

  Fly   165 RDGTTRRWMCHGFLACKDSGERLSHAVGCAF 195
            :..:..|:.||.|:: ::|.:.|:.::|.||
Frog   631 KHPSDHRFACHVFVS-EESTKPLAESIGRAF 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	34/143 (24%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
mapk8ip1	XP_031756343.1	SH3_JIP1	461..515	CDD:212876	8/53 (15%)
mapk8ip1	XP_031756343.1	PTB_JIP	531..680	CDD:269923	34/141 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910