Protein Alignment numb and numbl

DIOPT Version :9

• Sequence 1: NP_001260291.1
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_002938862.4
• Gene: numbl / 100488844
• XenbaseID: XB-GENE-961776
• Length: 588
• Species: Xenopus tropicalis
• Alignment Length: 646
• Identity: 221/646 - (34%)
• Similarity: 300/646 - (46%)
• Gaps: 189/646 - (29%)

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEAL 106
            |::||:|.|   |::...|||:|:||||.|||||||...|||.|:|||.|||.|||||.|||:|:
 Frog     1 MNKLRQSLR---RKKPTYVPEASRPHQWGADEEAVRRGKCSFPVRYLGHVEVEESRGMHVCEDAV 62

  Fly   107 KVLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERGFSYICRDGTTRR 171
            |.|:...::.|:.:|.||.||||||||:||.||||||||||||||||||.::.||||||||||||
 Frog    63 KKLKTLGKKSVKAILWVSADGLRVVDDKTKDLIVDQTIEKVSFCAPDRNFDKAFSYICRDGTTRR 127

  Fly   172 WMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFR-----QQ 231
            |:||.|:|.||||||||||||||||.||||||:|:||||||.:||...::|.|.||||     ||
 Frog   128 WICHCFMALKDSGERLSHAVGCAFAACLERKQKREKECGVTASFDASRTSFAREGSFRVTSASQQ 192

  Fly   232 TLTERLAMATVGTNERSVDGPG--SAMP--GPPAATVKPFNP--------------------FAI 272
            ...|.: |..:...:::...|.  |::|  |.|:..|.|..|                    .||
 Frog   193 AEREEV-MRQLQDKKKAEAAPSLTSSIPAVGAPSNPVLPAQPDQSPPQCATVPSEKSETGGQHAI 256

  Fly   273 ERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTPLRS 335
            .|.||....|.||.|||.....||  ||||||:|||:|:|||...|             :|..:.
 Frog   257 PRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQR-------------KTNFQD 308

  Fly   336 VSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSLLTQTDALLAAGEDLNFNNNRSINQ 400
            .|.:.|:.          |:....:|.::.||.:::...:.....|..      .|.|..|:.:.
 Frog   309 KSQVIELE----------SSMHPDSDGINDLCNQINSSFANKPSEDPF------ANSNGTRTPST 357

  Fly   401 NIIA--AEKQVQHVHSYAPPTAQVTPRVASTTPTYQTLHSQSPSRSEQSIETSTELPNAEQW--- 460
            ...|  ..:.:|.:..:|..|:.....|.     :|..|.::||.:|:.:|...:...|:|.
 Frog   358 GPAAPLPPQPMQGISGWAEQTSTSAAAVG-----FQMGHRRTPSEAERWLEEVAKAAKAQQQQPP 417

  Fly   461 ----------------------------LG-----HVVRSTSPAAPKRPT--------------- 477
                                        :|     |:..:..|.|...||
 Frog   418 PQPMVAVPMPVPAAVQAYPVSYDAATAPVGMFITPHMQAAYVPVAGYNPTMSYPAPSVPVVGITP 482

  Fly   478 --YLANVGRAQTLASGT-------------------------------GAAVGGGGPDDP----- 504
              .:|||..:.|....|                               |.|.|...|.||
 Frog   483 SQMVANVFCSATQVPSTNLANKSNPFPQSILQTSNASAQPSQMGPKPNGTANGTSWPPDPSQLRL 547

  Fly   505 ---------FDAEWVANVAAAKQLSPDLPIPSTARSPLARHSTNPFISPPKAPAQSFQVQL 556
                     |:|:|.|             :.|.::..||    |||.:..:   ::||::|
 Frog   548 ASTAQEVDQFEAQWAA-------------LESKSQQRLA----NPFSNELQ---KTFQIEL 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	98/133 (74%)
		NumbF	269..374	CDD:283874	35/126 (28%)
numbl	XP_002938862.4	PTB_Numb	23..157	CDD:241298	98/133 (74%)
		PHA03247	<206..563	CDD:223021	79/390 (20%)
		NumbF	255..337	CDD:399368	34/104 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I3225
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	302	1.000	Inparanoid score	I2629
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1110016at2759
OrthoFinder	1	1.000	-	-		FOG0003748
OrthoInspector	1	1.000	-	-		otm48696
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2695
SonicParanoid	1	1.000	-	-		X2613
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090