Protein Alignment numb and numb

DIOPT Version :10

• Sequence 1: NP_523523.2
• Gene: numb / 34263
• FlyBaseID: FBgn0002973
• Length: 556
• Species: Drosophila melanogaster
• Sequence 2: XP_012823284.1
• Gene: numb / 100038147
• XenbaseID: XB-GENE-854791
• Length: 654
• Species: Xenopus tropicalis
• Alignment Length: 631
• Identity: 230/631 - (36%)
• Similarity: 300/631 - (47%)
• Gaps: 176/631 - (27%)

  Fly    42 MDRLRRSFRDSFRRRKD-RVPESSKPHQWQADEEAVRSATCSFSVKYLGCVEVFESRGMQVCEEA 105
            |::||:    ||||:|| .|||:|:|||||.|||:||:..|||.|||||.|||.|||||.:||||
 Frog     1 MNKLRQ----SFRRKKDIYVPEASRPHQWQTDEESVRNGKCSFQVKYLGHVEVEESRGMHICEEA 61

  Fly   106 LKVLRQSR-----------RRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNHERG 159
            :|.|:..|           ::.::.:|.||.|||||||::||.|:||||||||||||||||.:|.
 Frog    62 VKRLKSERKYFKGFFAKSGKKAIKAVLWVSADGLRVVDEKTKDLLVDQTIEKVSFCAPDRNFDRA 126

  Fly   160 FSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTR 224
            |||||||||||||:||.|:|.||:|||||||||||||.||||||:|:||||||.|||...:||||
 Frog   127 FSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTR 191

  Fly   225 TGSFRQQTLTERL----AMATVGTNERSVDGPGSAMPGPPAATV--------------------- 264
            .||||..|.||:.    .|..:..:.:.::.....:|..|:.||
 Frog   192 EGSFRVTTATEQAEREEVMKQIQESRKELEVKAPVVPAAPSTTVSSTPTPVLQSSPTSEVFVVQD 256

  Fly   265 -KPFN-PFAIERPHATPNMLERQSSFRLSTIGSQ--SPFKRQMSLRINDLPSNADRQRAFLTAAA 325
             |..| |.||.|.||....|.||.|||.....||  ||||||:|||||:|||...|:..|
 Frog   257 SKDLNYPHAIPRRHAPVEQLARQGSFRGFPALSQKMSPFKRQLSLRINELPSTVQRKSDF----- 316

  Fly   326 GNPMQTPLRSVSPIAEVSPAKSAGADPLSAAAVAADSVSQLCQELSQGLSL--------LTQTDA 382
                    ::.:|:||:....              ||:|.||.:::...|:        ...|.|
 Frog   317 --------QATNPVAEMEGEN--------------DSISALCSQITNTFSMPPEDPFTSAPMTKA 359

  Fly   383 LLAAGEDLNFNNNRSINQNIIAAEKQVQHVHSYAPPTAQVTP----RVASTTP------------ 431
            ..........|...|......|....:....:.|.|..:..|    ..||..|
 Frog   360 TTPQSPPFEVNGTASAFSLPAATPTPISVTSTAAAPVRETNPWANAPAASNLPVTTTGTLSVAPL 424

  Fly   432 --------TYQTLHSQSPSRSEQSIETSTELPNAEQWLGHVVR------STSPAAPKRP------ 476
                    |:|:.|.::||             .|::||..|.:      |..||.|.:|
 Frog   425 VGPVPSSGTHQSNHKRTPS-------------EADRWLEEVSKTIMQRQSPVPAVPTQPMVQPAL 476

  Fly   477 -------TYLAN----------------------VGRAQTLASG-----TGAAVGGGGPDDPFDA 507
                   .||||                      |....::|:|     :...|.|..|     :
 Frog   477 AAPQPNQPYLANAYVTSQSMPVSVVPGLHPPFMPVQPPYSVANGMSYPASSVPVVGITP-----S 536

  Fly   508 EWVANV--AAAKQLSPDLPIPSTARS------PLARHSTNPFISPP 545
            :.||||  .|:.|:....|.|:.|..      ..:..|::||..||
 Frog   537 QMVANVFGVASPQVFQPKPSPNLATQQTYPTYEASSASSSPFYKPP 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_523523.2	PTB_Numb	67..201	CDD:241298	96/144 (67%)
		NumbF	269..374	CDD:461874	38/106 (36%)
numb	XP_012823284.1	PTB_Numb	23..168	CDD:241298	104/155 (67%)
		Atrophin-1	<224..>580	CDD:460830	90/370 (24%)
		NumbF	263..343	CDD:461874	21/87 (24%)