DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and mapk8ip2

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001090670.1	Gene:	mapk8ip2 / 100036643	XenbaseID:	XB-GENE-484342	Length:	1016	Species:	Xenopus tropicalis

Alignment Length:	249	Identity:	54/249 - (21%)
Similarity:	90/249 - (36%)	Gaps:	61/249 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GNSSSHTHEPLERGFTR---------------GKFGDVKNGKS------ASFRFSKKSPKKMDRL 45
            |:||...:.|..:.|..               |.|..|.||:.      |.|||   .|:..|.|
Frog   754 GDSSPEPNMPFSKKFLNVFVNSTSRSSSTDSFGLFSCVINGEEREQTHRAVFRF---IPRHEDEL 815

  Fly    46 RRSFRD---------------SFRRRKDRVPESSKPHQ--WQADEEAVRSATC----SFSVKYLG 89
            .....|               :.|..:..:..|...|:  ....|..|.....    .|..::||
Frog   816 ELDVDDPLLVECEDGSWCRGYNMRTGERGIFPSFYAHEVVCPVKENVVLRGNSPWVQMFDAQFLG 880

  Fly    90 CVEVFESRGMQVCEEALKVLRQSR------RRPVRGLLHVSGDGLRVV-------DDETKGLIVD 141
            .|||...:|..:...|::.:..:|      |.|....|.:|..|::::       :||.......
Frog   881 SVEVPNHQGNGILCAAMQKIATARKLTVHLRPPASCELEISLRGVKLILRGNDRPEDERCSHFFQ 945

  Fly   142 QTIEKVSFCAPDRNHERGFSYICRDGTTRRWMCHGFLACKDSGERLSHAVGCAF 195
              ::.:|||.....:...|.:|.:.....|:.||.|:: :||..|::..:|.||
Frog   946 --MKNISFCGCHPRNSCYFGFITKHPVLNRFACHVFVS-QDSMRRVAECLGRAF 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	34/148 (23%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
mapk8ip2	NP_001090670.1	SH3	800..853	CDD:302595	10/55 (18%)
mapk8ip2	NP_001090670.1	PTB_JIP	870..1016	CDD:269923	31/130 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910