DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment numb and Ldlrap1

DIOPT Version :9

Sequence 1:	NP_001260291.1	Gene:	numb / 34263	FlyBaseID:	FBgn0002973	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_663529.2	Gene:	Ldlrap1 / 100017	MGIID:	2140175	Length:	308	Species:	Mus musculus

Alignment Length:	239	Identity:	61/239 - (25%)
Similarity:	100/239 - (41%)	Gaps:	36/239 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 MDRLRRSFRDSFRRRKDRVPESSK-----------PHQWQADEEAVRSATCSFSVKYLGCVEVFE 95
            ||.|:     |..|...|.|..:|           |..|....|.:..... ||:||||...|..
Mouse     1 MDALK-----SAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMV-FSLKYLGMTLVER 59

  Fly    96 SRGMQVCEEALK----VLRQSRRRPVRGLLHVSGDGLRVVDDETKGLIVDQTIEKVSFCAPDRNH 156
            .:|.::...|:|    ..:.|.::..:..|.||..|:.:.|..|..||.:.:|.::|:|..|:.|
Mouse    60 PKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMH 124

  Fly   157 ERGFSYICRDGTTRRWMCHGFLACKDS-GERLSHAVGCAFAVCL-------ERKQRRDK--ECGV 211
            ::.|:||.:........||.||..|.. .:.::..|..||.|..       |.|::|:|  :.|.
Mouse   125 DKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGG 189

  Fly   212 TMTFDTKNS-----TFTRTGSFRQQTLTERLAMATVGTNERSVD 250
            .:....::|     |...||:........:..::||..|..:||
Mouse   190 DVPGTRRDSTPSLKTLVATGNLLDLEEVAKAPLSTVSANTNNVD 233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
numb	NP_001260291.1	PTB_Numb	67..201	CDD:241298	38/145 (26%)
numb	NP_001260291.1	NumbF	269..374	CDD:283874
Ldlrap1	NP_663529.2	PTB_LDLRAP-mammal-like	43..165	CDD:269981	34/122 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..201		4/21 (19%)
		Clathrin box. /evidence=ECO:0000250\|UniProtKB:Q5SW96	211..215		0/3 (0%)
		AP-2 complex binding. /evidence=ECO:0000250\|UniProtKB:Q5SW96	248..275
		[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif. /evidence=ECO:0000250\|UniProtKB:Q5SW96	256..265
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	288..308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840