Protein Alignment Mco1 and GMC1

DIOPT Version :10

• Sequence 1: NP_609287.3
• Gene: Mco1 / 34258
• FlyBaseID: FBgn0032116
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_010794.3
• Gene: GMC1 / 852117
• SGDID: S000002914
• Length: 608
• Species: Saccharomyces cerevisiae
• Alignment Length: 743
• Identity: 148/743 - (19%)
• Similarity: 244/743 - (32%)
• Gaps: 301/743 - (40%)

  Fly   308 GPAIEVCEGDEIVVDVKNHLLGE--------------STSIHWHGLHQKKTPYMDGVPHITQCPI 358
            ||.|.|..||.:.:.:.|.:..|              ||::|:||:......: ||:|.:||..|
Yeast    59 GPEIRVKSGDTLNLKLTNWICSEEEASKDSDVWKDYCSTALHFHGVVPLANEF-DGIPGLTQPTI 122

  Fly   359 TPHATFRYSFPADLS--GTHFWHSHTGMQRGDGVFGALII------------------------- 396
            ....::.|:|..|.|  ||.::|||:.:|.|||:.|.||:
Yeast   123 GYGESYWYNFTIDQSTCGTFWYHSHSSVQYGDGMRGVLIVECDDYDNHVANTINSVRDIETLDDG 187

  Fly   397 ----RKPK-TAEPHGGLYDFDLSEHVMIVQDW-------------IHDTGASIFSYHHHSRGDNK 443
                :|.| |.|    |.|:::.|.::.:.||             :..||.:          |.|
Yeast   188 VVTMKKDKHTKE----LTDYEVQERIITLSDWYTNWNLDILNDKVLSSTGGT----------DPK 238

  Fly   444 PHNLLVNGKGRYYNRIWAEAKQAHRRAEERTTQPVEPLPKSQVDFVQTLPRQARLAKTNTTKLFP 508
            ....|:|||
Yeast   239 FDGSLINGK-------------------------------------------------------- 247

  Fly   509 VNSRQKRGNLNEIPLELVPHQIYTVRRGFRYRFRIINAEYLNCPIVVS---------IDGHNLTA 564
                ...|.              |::.||       |.|||...||.|         :||..|..
Yeast   248 ----SSDGE--------------TIKIGF-------NTEYLLLRIVNSGMSGTQVFHLDGFQLIV 287

  Fly   565 INSDGFDIEAMDVGSIVTYSGERFDFVLNANLEVGNYWIRLKGLMDCSEVFTSAFQVAILRYEGA 629
            :.:||..|:...|.:|....|:|:..::  .|:....:||:  :..|:::.....:......|||
Yeast   288 LEADGIMIKPFIVQTINLAVGQRYTILV--KLKSDTSFIRM--INGCNKMMGYITKQWWFYKEGA 348

  Fly   630 PDEEP--TAELSYGHKAEGIELNVMNRGPGYPDTKTVAEMRALPIYDHVSGIDHDTLK------P 686
            ..:.|  ..::|..|.            ||:    |.||     :|..:.....:..|      |
Yeast   349 HLDLPKNPNDVSIEHL------------PGF----TKAE-----LYRDIEPTQEENKKLRTKADP 392

  Fly   687 EADYKF-FIYYDFYTKNNPDFHDKDLYAMDMEMTQQNRLYTPQLNHITLNFPSLALLPSRSQLKD 750
            .|.::| :.||       .|...|..|...|....:........:.:...|
Yeast   393 VAVFEFDYAYY-------KDESTKQKYGTGMYKVNERTFSEYVKDPVRFGF-------------- 436

  Fly   751 SDFCNET-SLMDQGIDCRQEFCKCHHVLQVPLGAVVEMIIVDEGFQYYANHPFHLHGNAFRVMGL 814
                ||| .::...:|                               :..||:|:||:.|:::.|
Yeast   437 ----NETYDIVINSLD-------------------------------HMRHPWHMHGHHFQIISL 466

  Fly   815 ERLGENVTVEMIKQLDQFNLLKRNLDN-------PPVKDTVTIPDGGYTIIRFEASNPGYWLFHC 872
            ...|:....:.:::...::..:.:|.:       |.|:|::.|....|.::|.....||.||.||
Yeast   467 GNKGDGPFHKDVQEGKAWSRYQNDLRHLARTGKAPMVRDSINIAGNSYAVLRINTEMPGKWLLHC 531

  Fly   873 HIEFHAEIGMALVFKVGNDDQMVPVPENFPTCGDYNPDLRSDGGTTEDSGS-------SKPITAT 930
            |:|:|...|:.:||:|             ||             |||||..       |.|....
Yeast   532 HVEWHMMKGLGIVFEV-------------PT-------------TTEDSTKQATTAVLSYPTKEP 570

  Fly   931 PPNTGGGGSGLEPTWITLMISSMLVKLY 958
            .|||....:.||..      .|.::.:|
Yeast   571 DPNTVVHTAALEQN------KSKVIAVY 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mco1	NP_609287.3	VWC	150..212	CDD:214564
		CuRO_1_tcLCC2_insect_like	293..397	CDD:259927	35/133 (26%)
		CuRO_2_tcLCC_insect_like	415..626	CDD:259951	36/232 (16%)
		CuRO_3_tcLLC2_insect_like	728..897	CDD:259972	33/176 (19%)
GMC1	NP_010794.3	CuRO_1_MCO_like_2	29..164	CDD:259932	35/105 (33%)
		CuRO_2_Fet3p_like	206..345	CDD:259945	36/233 (15%)
		Cupredoxin	<435..547	CDD:473140	32/160 (20%)