Protein Alignment Mco1 and Heph

DIOPT Version :10

• Sequence 1: NP_609287.3
• Gene: Mco1 / 34258
• FlyBaseID: FBgn0032116
• Length: 959
• Species: Drosophila melanogaster
• Sequence 2: NP_034547.2
• Gene: Heph / 15203
• MGIID: 1332240
• Length: 1157
• Species: Mus musculus
• Alignment Length: 757
• Identity: 154/757 - (20%)
• Similarity: 233/757 - (30%)
• Gaps: 272/757 - (35%)

  Fly   308 GPAIEVCEGDEIVVDVKNHLLGESTSIHWHGLHQKK----TPYMDGVPH---------IT-QCPI 358
            ||.|....||.|.|...|. ..:..||..||:..:|    |.|.||..|         :| ...:
Mouse   457 GPVIRAEVGDTIQVVFYNR-ASQPFSIQPHGVFYEKNSEGTVYNDGTSHPKVAKSFEKVTYYWTV 520

  Fly   359 TPHATFRYSFPADLSGTHFWHSHTGMQRGDGVFGALIIRKP------------------------ 399
            .|||......||.|:..:|..:........|:.|.|::.|.
Mouse   521 PPHAGPTAQDPACLTWMYFSAADPTRDTNSGLVGPLLVCKAGALGADGKQKGVDKEFFLLFTVFD 585

  Fly   400 ------KTAEPHGGLYDFD-LSEHVMIVQD--WIHDTGASIFSYHHH---SRGDNKPHNLLVNGK 452
                  ..|....|:.|.. |||.|...||  .:|.....:||....   .:||....:||  |.
Mouse   586 ENESWYNNANQAAGMLDSRLLSEDVEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLL--GL 648

  Fly   453 GRYYNRIWAEAKQAHRRAEERTTQPVEPLPKSQV-----DFVQTLPRQARLAKTNTTKLFPVNSR 512
            |        .....|....|..|..::.:.|..|     .||      ..:.:.:...:|.:..
Mouse   649 G--------TETDVHGVMFEGNTVQLQGMRKGAVMLFPHTFV------TAIMQPDNPGIFEIYC- 698

  Fly   513 QKRGNLNEIPLELV------------PHQIYTVRRGFRYRFRIINAEYLNCP-IVVSIDGHNLT- 563
             :.|:..|..::.:            |.|.|...|.:......|..:|  || ....::.||.:
Mouse   699 -QAGSHREEGMQAIYNVSQCSSHQDSPRQHYQASRVYYIMAEEIEWDY--CPDRSWELEWHNTSE 760

  Fly   564 --------AINSDG------------------FDIEAM-----------------DVGSIVTYSG 585
                    ..|.||                  |.|...                 :||.|:|
Mouse   761 KDSYGHVFLSNKDGLLGSKYKKAVFREYTDGTFRIPRPRSGPEEHLGILGPLIRGEVGDILT--- 822

  Fly   586 ERFDFVLNANLEVGNYWIRLKGLMDCSEVFTSAFQVAILRYEGAPD-EEPTAELSYGHKAEGIEL 649
                 |:..|.....|.|...|:::.:              .|.|. .||...|:|       :.
Mouse   823 -----VVFKNKASRPYSIHAHGVLESN--------------TGGPQAAEPGEVLTY-------QW 861

  Fly   650 NVMNR-GPGYPDTKTVAEM---RALPIYDHVSGI-------DHDTLKP-----EADYKF---FIY 695
            |:..| |||..|:..|:.:   ...||.|..||:       .:..|:|     :.|.:|   |:.
Mouse   862 NIPERSGPGPSDSACVSWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGGRNDMDREFALLFLI 926

  Fly   696 YDFYTKNNPDFHDKDLYAMDMEMTQQNRLYTPQLNHITLNFPSLALLPSRSQLKDSDFCNETSLM 760
            :|    .|..::.|:..|          .|.||.:             |...|||:.|.....:
Mouse   927 FD----ENQSWYLKENIA----------TYGPQES-------------SHVNLKDATFLESNKM- 963

  Fly   761 DQGIDCRQEFCKCHHVLQVPLGAVVEMIIVDEG--FQYYA--------NHPFHLHGNAFRVMGLE 815
                          |.:...|.|.:..:.|.:|  ..:|.        .|..|.|..:|    |.
Mouse   964 --------------HAINGKLYANLRGLTVYQGERVAWYMLAMGQDTDIHTVHFHAESF----LY 1010

  Fly   816 RLGENVTVEMIKQLDQFNLLKRNLDNPPVKDTVTIPDGGYTIIRFEASNPGYWLFHCHIEFHAEI 880
            :.|::...                      |.|.:..|.:.::...|||||.||.|||:..|...
Mouse  1011 QNGQSYRA----------------------DVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHA 1053

  Fly   881 GMALVFKVGNDDQMVPVPENFPTCGDYNPD------LRSDGG 916
            ||..:|.|.:.:      |:|.|......:      ||..||
Mouse  1054 GMETIFTVLSHE------EHFSTMTTITKEIGKAVILRDIGG 1089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mco1	NP_609287.3	VWC	150..212	CDD:214564
		CuRO_1_tcLCC2_insect_like	293..397	CDD:259927	29/102 (28%)
		CuRO_2_tcLCC_insect_like	415..626	CDD:259951	47/277 (17%)
		CuRO_3_tcLLC2_insect_like	728..897	CDD:259972	36/178 (20%)
Heph	NP_034547.2	CuRO_1_ceruloplasmin	26..208	CDD:259884
		CuRO_2_ceruloplasmin	223..363	CDD:259907
		CuRO_3_ceruloplasmin	377..571	CDD:259886	30/114 (26%)
		Cupredoxin	574..717	CDD:473140	28/160 (18%)
		CuRO_5_ceruloplasmin	732..903	CDD:259887	39/201 (19%)
		Cupredoxin	919..1062	CDD:473140	43/210 (20%)