DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT27 and krtt1c19e

DIOPT Version :9

Sequence 1:	NP_853515.2	Gene:	KRT27 / 342574	HGNCID:	30841	Length:	459	Species:	Homo sapiens
Sequence 2:	NP_001107814.1	Gene:	krtt1c19e / 553371	ZFINID:	ZDB-GENE-050506-95	Length:	473	Species:	Danio rerio

Alignment Length:	463	Identity:	200/463 - (43%)
Similarity:	282/463 - (60%)	Gaps:	33/463 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSVRFSSTSRRLGSCGGTGSVRLSS-------GGAGFGAG-----NTCGVPGIGSGFSCAFGGS- 52
            :|.|.|..|.||.|.||.|. |:|:       |||| |||     .:..:...|||.:..|||.
Zfish    11 VSSRSSMGSSRLSSSGGGGG-RISAMRSGSVYGGAG-GAGVRISSASRSMSAAGSGGNFGFGGGF 73

Human    53 SSAGGYGGGLGGGSASCAAFTGNEHGL---------LSGNEKVTMQNLNDRLASYLENVRALEEA 108
            .||||.|.|.|.|....||..|...|:         :.||||.|:|||||||||||:.||:||:|
Zfish    74 GSAGGAGAGFGAGGGFGAAAGGGFWGIGASGAADDSIIGNEKFTLQNLNDRLASYLDKVRSLEKA 138

Human   109 NADLEQKIKGWYE-KFGPGSCRGLDHDYSRYFPIIDELKNQIISATTSNAHVVLQNDNARLTADD 172
            ||:||.||:.:.| |..|   .|...:||.:..::.:|:.:|::|...|..|.|..||:.|.|||
Zfish   139 NAELELKIREFLENKISP---TGAARNYSAFETVVSDLQAKILAAIQLNNTVHLSIDNSSLAADD 200

Human   173 FRLKFENELALHQSVEADINGLRRVLDELTLCRTDLEIQLETLSEELAYLKKNHEEEMKALQCAA 237
            ||:|:||||::.|||||||.||:.||.:|.:.:.||.:|:|.|:|||||:|.||:|::...:...
Zfish   201 FRIKYENELSMRQSVEADIAGLKNVLSDLNMGQKDLNLQIEALTEELAYMKANHQEDLSTSRDQM 265

Human   238 GGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFNEKSASLQQQISDDAGATTSARN 302
            .|.||||::|||..|||.:|.::|..||.:..:::|:.|.||.:||.:|:|::........:::.
Zfish   266 SGQVNVEVDAAPQEDLTKVLADIREHYETVVSKSQRELEGWFQQKSETLKQEVVASTETLQTSKT 330

Human   303 ELIEMKRTLQTLEIELQSLLATKHSLECSLTETESNYCAQLAQIQAQIGALEEQLHQVRTETEGQ 367
            |:..:|.::|:||||||||||.|.|:|.:|.:|::.|..||:..|||:..:|.||.|:|.:.|.|
Zfish   331 EVNSVKSSVQSLEIELQSLLAMKSSMEGTLNDTQNRYSMQLSGYQAQVSGMEGQLVQLRADLERQ 395

Human   368 KLEYEQLLDIKVHLEKEIETYCLLIDGE-DGS--CSKSKGYGGPGNQTKDSSKTTIVKTVVEEID 429
            ..||:.|||||..||.||..|..|:|.| .||  .|...|.....:.|..::||.::..|.|.||
Zfish   396 GQEYQMLLDIKTRLEMEIAEYRRLLDAEASGSLAISSKSGSSSTSSSTTSTTKTAVITVVEEVID 460

Human   430 PRGKVLSS 437
              |||:||
Zfish   461 --GKVVSS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT27	NP_853515.2	Head. /evidence=ECO:0000255	1..83		37/103 (36%)
		Filament	83..396	CDD:278467	146/314 (46%)
		Coil 1A. /evidence=ECO:0000255	84..119		25/34 (74%)
		Linker 1. /evidence=ECO:0000255	120..141		6/21 (29%)
		Coil 1B. /evidence=ECO:0000255	142..233		45/90 (50%)
		SPEC	178..375	CDD:295325	86/196 (44%)
		Linker 12. /evidence=ECO:0000255	234..256		11/21 (52%)
		Coil 2. /evidence=ECO:0000255	257..395		57/137 (42%)
		Tail. /evidence=ECO:0000255	396..459		16/44 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..459		2/2 (100%)
krtt1c19e	NP_001107814.1	Filament	113..423	CDD:278467	145/312 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23239
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910