DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4438 and PDAP1

DIOPT Version :9

Sequence 1:	NP_001188753.1	Gene:	CG4438 / 34257	FlyBaseID:	FBgn0032115	Length:	189	Species:	Drosophila melanogaster
Sequence 2:	NP_055706.1	Gene:	PDAP1 / 11333	HGNCID:	14634	Length:	181	Species:	Homo sapiens

Alignment Length:	197	Identity:	79/197 - (40%)
Similarity:	117/197 - (59%)	Gaps:	43/197 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPR-GKFLSYKGRTRQFTSPEEL-------RQESEDDYDQ-VSGSGSDSDEKVATRGGANSSSSI 56
            ||: |:...:|||.||:|||||:       :|::.::.:| ..|.|:..|.|
Human     1 MPKGGRKGGHKGRARQYTSPEEIDAQLQAEKQKAREEEEQKEGGDGAAGDPK------------- 52

  Fly    57 AKDRTLKKATRNQKS-SSDEVDSSSEDCETESRVARKGVASLIEIDNPNRVSKKGPQKISAIMLD 120
                      :.:|| .|||    |||.|.:.:..||||..||:|:|||||::. .:|::.:.||
Human    53 ----------KEKKSLDSDE----SEDEEDDYQQKRKGVEGLIDIENPNRVAQT-TKKVTQLDLD 102

  Fly   121 QTKAGLSRRDQD----QSARKRYEKLHVAGKTTEARADLARLALIRKQREETAARREAEKKAANV 181
            ..|. ||||:::    |.|::||.|:|:||||.:|:|||||||:|||||||.|.::|.|:||.:.
Human   103 GPKE-LSRREREEIEKQKAKERYMKMHLAGKTEQAKADLARLAIIRKQREEAARKKEEERKAKDD 166

  Fly   182 VT 183
            .|
Human   167 AT 168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4438	NP_001188753.1	PP28	101..177	CDD:287254	41/79 (52%)
PDAP1	NP_055706.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..117		48/144 (33%)
		PP28	85..149	CDD:402043	33/65 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..181		8/18 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154938
Domainoid	1	1.000	96	1.000	Domainoid score	I7340
eggNOG	1	0.900	-	-		E1_KOG3375
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4548
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60099
OrthoDB	1	1.010	-	-		D1572985at2759
OrthoFinder	1	1.000	-	-		FOG0004630
OrthoInspector	1	1.000	-	-		otm40620
orthoMCL	1	0.900	-	-		OOG6_105501
Panther	1	1.100	-	-	O	PTHR22055
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5851
SonicParanoid	1	1.000	-	-		X3831
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800