DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aldh and aldB

DIOPT Version :9

Sequence 1:	NP_001260290.1	Gene:	Aldh / 34256	FlyBaseID:	FBgn0012036	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_418045.4	Gene:	aldB / 948104	ECOCYCID:	EG12292	Length:	512	Species:	Escherichia coli

Alignment Length:	489	Identity:	205/489 - (41%)
Similarity:	292/489 - (59%)	Gaps:	22/489 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 FINNEWHKSKSGKIFETINPTTAEVIAEIQCADKEDIDIAVQAARNAFKLGSPWRRMDASERGRL 107
            ||..||.....|:.::.:.|.|.:::.|:..:.|.|||:|:.||.   |:...|......:|..:
E. coli    28 FIGGEWVAPADGEYYQNLTPVTGQLLCEVASSGKRDIDLALDAAH---KVKDKWAHTSVQDRAAI 89

  Fly   108 LYRLADLMERDQVYLASLETLDNGKPYSMSYNVDLPTAIKNLRYFAGWADKNHGKTIPMDGDFFT 172
            |:::||.||::...||:.||.|||||...:...|:|.||.:.||||.......|....:|.:...
E. coli    90 LFKIADRMEQNLELLATAETWDNGKPIRETSAADVPLAIDHFRYFASCIRAQEGGISEVDSETVA 154

  Fly   173 YTRHEPVGVCGQIIPWNFPILMMAWKLGPALATGNTIVLKPAEQTSLTALYIAQLVKEAGFPEGV 237
            |..|||:||.|||||||||:||.:||:.||||.||.:|||||..|.|:.|.:.::|.:. .|.||
E. coli   155 YHFHEPLGVVGQIIPWNFPLLMASWKMAPALAAGNCVVLKPARLTPLSVLLLMEIVGDL-LPPGV 218

  Fly   238 VNVVPGF-GTAGAALANHCDVDKVAFTGSTDVG-KLIQLASGNTNLKRVTLELGGKSPNIILS-- 298
            ||||.|. |..|..||....:.||||||||:|| :::|.|:  .|:..||||||||||||..:
E. coli   219 VNVVNGAGGVIGEYLATSKRIAKVAFTGSTEVGQQIMQYAT--QNIIPVTLELGGKSPNIFFADV 281

  Fly   299 ----DTDMDYAVETAHFGLF-FNMGQCCCAGSRTFVEDKIYDEFVERSAERAKKRTVGNPFDLNT 358
                |...|.|:|  .|.|| ||.|:.|...||..|::.||:.|:||:..|.:....|||.|..|
E. coli   282 MDEEDAFFDKALE--GFALFAFNQGEVCTCPSRALVQESIYERFMERAIRRVESIRSGNPLDSVT 344

  Fly   359 EQGPQVNEEQMEKILGMIKTGKKQGAKLVAGGSRP--EG--LPGYFVQPTVFADVQDDMTIAREE 419
            :.|.||:..|:|.||..|..|||:||.::.||.|.  ||  ..||:::||:... |::|.:.:||
E. coli   345 QMGAQVSHGQLETILNYIDIGKKEGADVLTGGRRKLLEGELKDGYYLEPTILFG-QNNMRVFQEE 408

  Fly   420 IFGPVQQLIRFKKLDEVIERANNSEYGLAAAVFTKDLDKANYIVGGLRAGTVWVNTYNVLAAQAP 484
            |||||..:..||.::|.:|.||:::|||.|.|::::.:.|..:..|::||.||.|.|:...|.|.
E. coli   409 IFGPVLAVTTFKTMEEALELANDTQYGLGAGVWSRNGNLAYKMGRGIQAGRVWTNCYHAYPAHAA 473

  Fly   485 FGGYKMSGHGRENGEYALSNYTEVKSVIVKVAQK 518
            |||||.||.|||..:..|.:|.:.|.::|..:.|
E. coli   474 FGGYKQSGIGRETHKMMLEHYQQTKCLLVSYSDK 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh	NP_001260290.1	PLN02466	9..512	CDD:215259	203/481 (42%)
Aldh	NP_001260290.1	ALDH_F1AB_F2_RALDH1	34..514	CDD:143459	203/483 (42%)
aldB	NP_418045.4	ALDH_ACDHII_AcoD-like	25..504	CDD:143471	204/484 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000158
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100163
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X158
SwiftOrtho	1	1.000	-	-
	6	5.710